Research News
RAPID: High-resolution agent-based modeling of COVID-19 spreading in a small town
COVID 19 has wreaked havoc across the planet. As of January 1, 2021, the WHO has reported nearly 82 million cases globally, with over 1.8 million deaths. In the face of this upheaval, public health authorities and the general population are striving to achieve a balance between safety and normalcy. The uncertainty and novelty of the current conditions call for the development of theory and simulation tools that could offer a fine resolution of multiple strata of society while supporting the evaluation of “what-if” scenarios.
The research team led by Maurizio Porfiri proposes an agent-based modeling platform to simulate the spreading of COVID-19 in small towns and cities. The platform is developed at the resolution of a single individual, and demonstrated for the city of New Rochelle, NY — one of the first outbreaks registered in the United States. The researchers used New Rochelle not only because of its place in the COVID timeline, but because agent-based modelling for mid-size towns are relatively unexplored despite the U.S. being largely composed of small towns.
Supported by expert knowledge and informed by officially reported COVID-19 data, the model incorporates detailed elements of the spreading within a statistically realistic population. Along with pertinent functionality such as testing, treatment, and vaccination options, the model also accounts for the burden of other illnesses with symptoms similar to COVID-19. Unique to the model is the possibility to explore different testing approaches — in hospitals or drive-through facilities— and vaccination strategies that could prioritize vulnerable groups. Decision making by public authorities could benefit from the model, for its fine-grain resolution, open-source nature, and wide range of features.
The study had some stark conclusions. One example: the results suggest that prioritizing vaccination of high-risk individuals has a marginal effect on the count of COVID-19 deaths. To obtain significant improvements, a very large fraction of the town population should, in fact, be vaccinated. Importantly, the benefits of the restrictive measures in place during the first wave greatly surpass those from any of these selective vaccination scenarios. Even with a vaccine available, social distancing, protective measures, and mobility restrictions will still key tools to fight COVID-19.
The research team included Zhong-Ping Jiang, professor of electrical and computer engineering; post-docs Agnieszka Truszkowska, who led the implementation of the computational framework for the project, and Brandon Behring; graduate student Jalil Hasanyan; as well as Lorenzo Zino from the University of Groningen, Sachit Butail from Southern Illinois University, Emanuele Caroppo from the Università Cattolica del Sacro Cuore, and Alessandro Rizzo from Turin Polytechnic. The work was partially supported by National Science Foundation (CMMI1561134 and CMMI-2027990), Compagnia di San Paolo, MAECI (“Mac2Mic”), the European Research Council, and the Netherlands Organisation for Scientific Research.
Detection of Hardware Trojans Using Controlled Short-Term Aging
This research project is led by Department of Electrical and Computer Engineering Professors Farshad Khorrami and Ramesh Karri, who is co-founder and co-chair of the NYU Center for Cybersecurity, and Prashanth Krishnamurthy, a research scientist at NYU Tandon; and Jörg Henkel and Hussam Amrouch of the Computer Science Department of the Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
The project builds upon on-going research, funded by a $1.3 million grant from the Office of Naval Research, to create algorithms for detecting Trojans — deliberate flaws inserted into chips during fabrication — based on the short term aging phenomena in transistors.
It will focus on this physical phenomenon of short-term aging as a route to detecting hardware Trojans. The efficacy of short-term aging-based hardware Trojan detection has been demonstrated through simulations on integrated circuits (ICs) with several types of hardware Trojans through stochastic perturbations injected into the simulation studies. This DURIP project seeks to demonstrate hardware Trojan detection in actual physical ICs.
Khorrami explained that the new $359,000 grant will support the design and fabrication of 28nm chips with and without built-in trojans
"The supply chain in manufacturing chips is complex and most foundries are overseas. Once a chip is fabricated and returned to the customer, the question is if additional hardware has been included on the chip die for most likely malicious purposes," he said.
For this purpose, this DURIP project is proposing a novel experimental testbed consisting of:
• A specifically designed IC that contains Trojan-free and Trojan-infected variants of multiple circuits (e.g., cryptographic accelerators and micrcontrollers). This IC will be used for evaluation of the efficacy and accuracy of the hardware short-term aging based Trojan detection methods. To validate the Trojan detection methodology the team will use 3mm×3mm ICs with both Trojan-free and Trojan-infected variants of multiple circuits.
• AnFPGA-based interface module to apply clock signal and inputs to the fabricated IC and collect outputs.
• A fast switching programmable power supply for precise application of supply voltage changes to the IC’s being tested. The unit will apply patterns of supply voltages to the test chips to induce controllable and repeatable levels of short-term aging.
• Finally, a data analysis software module on a host computer for machine learning based device evaluation and anomaly detection (i.e., detection of hardware Trojans).
This testbed, a vital resource in the physical validation of the proposed NYU-KIT hardware Trojan detection methodology will also be a valuable resource for evaluating and validating other hardware Trojan detection techniques developed by NYU and the hardware security researchers outside of NYU. The testbed will therefore be a unique experimental facility for the hardware security community by providing access to (i) physical ICs with Trojan- free and Trojan-infected variants of circuits ranging from moderate-sized cryptographic circuits to complex microprocessors plus (ii) a generic FPGA-based interface to interrogate and test these ICs for Trojans according to their detection method.
Brain-Muscle Connectivity Network for Assessing Stroke NeuroRehabilitation
This project is led by S. Farokh Atashzar, assistant professor of electrical and computer engineering at NYU Tandon; and John-Ross Rizzo, assistant professor in the Departments of Rehabilitation Medicine and Neurology at NYU Langone Health, and of mechanical and aerospace and biomedical engineering at NYU Tandon.
Stroke, the leading cause of motor disabilities, is putting tremendous pressure on healthcare infrastructures because of an imbalance between an aging society and available neurorehabilitation resources. Thus, there has been a surge in the production of novel rehabilitative technologies for accelerating recovery. Despite the successful development of such devices, lack of objective standards besides clinical investigations using subjective measures have led to controversial recommendations regarding several devices, including robots.
This NSF/FDA Scholar-in-Residence project, designed to address the need for effective rehabilitative technologies, is focused on the design, implementation, and evaluation of a novel, objective, and robust algorithmic biomarker of recovery. Called Delta CorticoMuscular Information-based Connectivity (D-CMiC), the proposed algorithm-based protocol quantifies the connectivity between the central nervous system (CNS) and the peripheral nervous system (PNS) by simultaneously measuring electrical activity from the brain and an ankle muscle on the affected side of recovering post-stroke patients. The system will quantify both spectrotemporal neurophysiological connectivity between the CNS (using electroencephalography (EEG) and PNS (using high-density surface electromyography (HD-sEMG).
The goal of the collaborative project, beyond clarifying the neurophysiology of recovery, is to expedite availability of more effective rehabilitation devices to patients for a range of neurological disorders beyond stroke (such as Parkinson's disease, Essential Tremor and Ataxia). For educational impact, the project will generate a unique transdisciplinary educational environment by conducting workshops about emerging Brain-Computer Interface (BCI) technologies in medicine, and undergraduate team projects for human-machine interfacing, with a focus on promoting STEM activities within underrepresented groups.
The predictive capability, precision, and efficiency of the developed D-CMiC metric will be analyzed by collecting data from recovering stroke patients and healthy subjects alike. Unique D-CMiC features include: (1) accurately and objectively tracking corticomuscular functional connectivity in the Delta/low frequency band; (2) computationally modeling of corticomuscular connectivity; (3) building the basis for the first medical device development tool for the systematic, objective, and transparent evaluation of pre-market rehabilitation devices, aligned with the FDA's mission.
RAPID: Visualizing Epidemical Uncertainty for Personal Risk Assessment
The National Science Foundation RAPID grant for this research was obtained by Rumi Chunara and Enrico Bertini, professors in the Department of Computer Science and Engineering.
COVID-19 is one of the most deadly and fastest transmitting viruses in modern history. In response to this pandemic, news agencies, government organizations, citizen scientists, and many others have released hundreds of visualizations of pandemic forecast data. While providing people with accurate information is essential, it is unclear how the average person understands the widely distributed depictions of pandemic data. Prior research on uncertainty communication shows that even common visualizations can be confusing. One possible source of inappropriate responses to COVID-19 is the lack of knowledge about personal risk and the nature of pandemic uncertainty.
The goal of this research is to test how people understand currently available COVID-19 data visualizations and create communication guidelines based on these findings. Further, the researchers will develop an application to help people understand the factors that contribute to their risk. Users are able to interact with the application to learn about the impact of their actions on their risk. This research provides immediate solutions for teaching people about their personal risk associated with COVID-19 and how their actions influence the risks of others, which could improve the public's response and decrease fatalities. Additionally, this work supports decision making for future pandemics and any subsequent outbreaks of COVID-19 or other viruses.
Specifically, the research team, in an effort to understand how people respond to uncertainty about the nature of the pandemic, is testing the effects of currently available visualizations on personal risk judgments and behavior. By studying how changes in factors influence risk perceptions, the research can contribute to understanding how people conceptualize compound uncertainties from different sources (e.g., uncertainties associated with location, time, demographics and risk behaviors). The researchers are using this information to produce a visualization application that allows people to change the parameters of a simulation to see how the resulting changes affect their risk judgments. For example, users in one city are able to see the pandemic risk to individuals of their age in their zip code and then see how that risk would change if the infection rate increased or decreased.
The aim is to promote intuitive understanding of the epidemiological uncertainty in the forecast through participants? experimentation with the application. While in line with current recommendations for intrinsic uncertainty visualization, this work is the first of its kind to test the effect of user interaction to convey uncertainty through visualization.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
Resource constrained mobile data analytics assisted by the wireless edge
The National Science Foundation grant for this research was obtained by Siddharth Garg and Elza Erkip, professors of electrical and computer engineering, and Yao Wang, professor of computer science and engineering and biomedical engineering. Wang and Erkip are also members of the NYU WIRELESS research center.
Increasing amounts of data are being collected on mobile and internet-of-things (IoT) devices. Users are interested in analyzing this data to extract actionable information for such purposes as identifying objects of interest from high-resolution mobile phone pictures. The state-of-the-art technique for such data analysis employs deep learning, which makes use of sophisticated software algorithms modeled on the functioning of the human brain. Deep learning algorithms are, however, too complex to run on small, battery constrained mobile devices. The alternative, i.e., transmitting data to the mobile base station where the deep learning algorithm can be executed on a powerful server, consumes too much bandwidth.
This project that this NSF funding will support seeks to devise new methods to compress data before transmission, thus reducing bandwidth costs while still allowing for the data to be analyzed at the base station. Departing from existing data compression methods optimized for reproducing the original images, the team will develop a means of using deep learning itself to compress the data in a fashion that only keeps the critical parts of data necessary for subsequent analysis. The resulting deep learning based compression algorithms will be simple enough to run on mobile devices while drastically reducing the amount of data that needs to be transmitted to mobile base stations for analysis, without significantly compromising the analysis performance.
The proposed research will provide greater capability and functionality to mobile device users, enable extended battery lifetimes and more efficient sharing of the wireless spectrum for analytics tasks. The project also envisions a multi-pronged effort aimed at outreach to communities of interest, educating and training the next generation of machine learning and wireless professionals at the K-12, undergraduate and graduate levels, and broadening participation of under-represented minority groups.
The project seeks to learn "analytics-aware" compression schemes from data, by training low-complexity deep neural networks (DNNs) for data compression that execute on mobile devices and achieve a range of transmission rate and analytics accuracy targets. As a first step, efficient DNN pruning techniques will be developed to minimize the DNN complexity, while maintaining the rate-accuracy efficiency for one or a collection of analytics tasks.
Next, to efficiently adapt to varying wireless channel conditions, the project will seek to design adaptive DNN architectures that can operate at variable transmission rates and computational complexities. For instance, when the wireless channel quality drops, the proposed compression scheme will be able to quickly reduce transmission rate in response while ensuring the same analytics accuracy, but at the cost of greater computational power on the mobile device.
Further, wireless channel allocation and scheduling policies that leverage the proposed adaptive DNN architectures will be developed to optimize the overall analytics accuracy at the server. The benefits of the proposed approach in terms of total battery life savings for the mobile device will be demonstrated using detailed simulation studies of various wireless protocols including those used for LTE (Long Term Evolution) and mmWave channels.
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
A survey of cybersecurity of digital manufacturing
This survey was led by Nikhil Gupta, professor mechanical and aerospace engineering and a member of the NYU Center for Cybersecurity; and Ramesh Karri, professor of electrical and computer engineering and co-founder and co-Chair of the NYU Center for Cybersecurity.
The Industry 4.0 concept promotes a digital manufacturing (DM) paradigm that can enhance quality and productivity, which reduces inventory and the lead time for delivering custom, batch-of-one products based on achieving convergence of additive, subtractive, and hybrid manufacturing machines, automation and robotic systems, sensors, com- puting, and communication networks, artificial intelligence, and big data. A DM system consists of embedded electronics, sensors, actuators, control software, and interconnectivity to enable the machines and the components within them to exchange data with other machines, components therein, the plant operators, the inventory managers, and customers.
Digitalization of manufacturing aided by advances in sensors, artificial intelligence, robotics, and networking technology is revolutionizing the traditional manufacturing industry by rethinking manufacturing as a service.
Concurrently, there is a shift in demand from high-volume manufacturing to batches-of-one, custom manufacturing of products. While the large manufacturing enterprises can reallocate resources and transform themselves to seize these opportunities, the medium-scale enterprises (MSEs) and small-scale enterprises with limited resources need to become federated and proactively deal with digitalization. Many MSEs essentially consist of general-purpose machines that give them the flexibility to execute a variety of process plans and workflows to create one-off products with complex shapes, textures, properties, and functionalities. One way the MSEs can stay relevant in the next-generation digital manufacturing (DM) environment is to become fully interconnected with other MSEs by using the digital thread and becoming part of a larger, cyber-manufacturing business network. This allows the MSEs to make their resources visible to the market and continue to serve as suppliers to OEMs and other parts of the manufacturing supply networks.
This article, whose authors include researchers from NYU Tandon and Texas A&M, explores the cybersecurity risks in the emerging DM context, assesses the impact on manufacturing, and identifies approaches to secure DM. It resents a hybrid-manufacturing cell, a building block of DM, and uses it to discuss vulnerabilities; discusses a taxonomy of threats for DM; explores attack case studies; surveys existing taxonomies in DM systems; and demonstrates how novel manufacturing-unique defenses can mitigate the attacks.
The team's research is supported, in part, by the National Science Foundation.
Spatiotemporal Decoupling of Water Electrolysis for Dual-Use Grid Energy Storage and Hydrogen Generation
This research is led by Miguel Modestino, assistant professor of chemical and biomolecular engineering and Yury Dvorkin, assistant professor of electrical and computer engineering.
Increased efforts to curb global warming have led to a drastic surge in the deployment of renewable electricity sources, such as wind and solar power. However, as these sources form a larger fraction of the energy in the grid, their intermittency has started to cause supply instability and large fluctuations in energy prices.
To mediate this challenge, electrochemical energy storage devices such as lithium ion batteries have started to enter the utility scale market. Also gaining traction are redox flow batteries (RFB) because of their long cycle life and power and energy capacity. Despite their promising performance RFB costs remain high due to low energy density of redox energy carriers, which results in large operational costs.
An alternative energy storage method is the production of energy-dense electrofuels, such as hydrogen (H2). H2 has gained significant attention as a promising energy vector for a renewable-rich energy future, given its high gravimetric energy density that makes it desirable for both stationary and mobile applications.
To make electrochemical hydrogen production more competitive, renewable energy sources need to be used with new strategies for electrochemical hydrogen production. The researchers, including Ph.D. students Daniel Frey (lead author) and Jip Kim, show a cerium-mediated decoupled electrolysis system that produces hydrogen and stores energy in the redox couples. They present electrochemical studies to observe the effects of diffusive transport, convective transport, and thermal effects. Following this, the team performed a techno-economic analysis, focusing on the optimization of the system operation and the identification of target operation parameters to achieve hydrogen production at a competitive price.
Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche
Weiqiang Chen, associate professor of biomedical and mechanical and aerospace engineering led this research.
B cell acute lymphoblastic leukemia (B-ALL) hijacks the bone marrow (BM) microenvironment to form leukemic BM “niches,” facilitating chemoresistance and, ultimately, disease relapse. The key to developing more effective, targeted therapies depends on researchers' ability to isolate and examine with these evolving, heterogeneous interactions among distinct B-ALL subtypes and their varying BM niches. Current in vivo methods limit that ability.
A team including researchers from the NYU Tandon School of Engineering's departments of Mechanical and Aerospace, and Biomedical Engineering, and from NYU Langone's Perlmutter Cancer Center and Department of Pathology demonstrated an in vitro organotypic “leukemia-on-a-chip” model to emulate the in vivo B-ALL BM pathology and comparatively studied the spatial and genetic heterogeneity of the BM niche in regulating B-ALL chemotherapy resistance.
In the study "Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche," published in ScienceAdvances, the team used their system to describe the heterogeneous chemoresistance mechanisms across various B-ALL cell lines and patient-derived samples, showing that the leukemic perivascular, endosteal, and hematopoietic niche-derived factors maintain B-ALL survival and quiescence. Furthermore, they demonstrated the preclinical use of their lab-on-a-chip model to test niche-cotargeting regimens, which may translate to patient-specific therapy screening and response prediction.
This work was supported by the National Science Foundation, the U.S. National Institutes of Health, the Leukemia & Lymphoma Society, the New York State Department of Health (NYSTEM Program), and the St. Baldrick’s Cancer Research Foundation (I.A).
Good for the Many or Best for the Few? A Dilemma in the Design of Algorithmic Advice
Oded Nov, professor of Technology Management and Innovation led this research.
Applications in a range of domains, including route planning and well-being, offer advice based on the social information available in prior users' aggregated activity.
A team of collaborators, including Graham Dove, a research assistant professor at NYU CUSP; Martina Balestra, a post-doc at NYU CUSP; and Devin Mann of NYU Grossman School of Medicine, considered a dilemma in the design of AI-based advice applications. Using an experiment, they studied whether, when designing these applications, it is better to offer:
• Goal-Directed advice: advice that is more likely to result in users who adhere to it achieving their goal, but which users are less likely to adopt and adhere to, or
• Adoption-Directed advice: advice that is more likely to be adopted and adhered to by a greater number of users, but which is less likely to result in a user fully achieving their goal
To explore this question the collaborators conducted an online experiment undertaken in four advice domains (financial investment, making healthier lifestyle choices, route planning, training for a 5k run), with three user types, and across two levels of uncertainty. Their findings suggest a preference for advice favoring individual goal attainment over higher user adoption rates, albeit with significant variation across advice domains; and discuss their design implications. The research is published in the Proceedings of the ACM on Human-Computer Interaction.
AI-powered and Robot-assisted Manufacturing for Modular Construction
Semiha Ergan, assistant professor in the Departments of Civil and Urban Engineering, and Computer Science and Engineering and Chen Feng, assistant professor in the departments of Civil and Urban and Mechanical and Aerospace Engineering will lead this project.
Modular construction, with an established record of accelerating projects and reducing costs, is a revolutionary way to transform the construction industry. However, new construction capabilities are needed to perform modular construction at scale, where, as is the case in factories, the industry suffers from the dependency on skilled labor. Among the challenges this project aims to address:
- Every project is unique and requires efficiency and accuracy in recognition and handling workpieces
- Design and production-line changes are common, and require design standardization and optimization of modules, and
- Production lines are complex in space and time, and necessitate the guidance of workers while processing design and installation information accurately
To focus on these challenges while exploring modular construction within the context of Future Manufacturing (FM), this project exploits opportunities at the intersection of AI/robotics/building information modeling and manufacturing, with the potential to increase the scalability of modular construction.
The research will pioneer initial formulations to enable (a) high throughput in manufacturing through the definition and evaluation of processes that embrace real-time workpiece semantic grounding and in-situ AR-robotic assistance, (b) feasibility studies of optimizing and standardizing the design of modules, and utilization of a cyber-infrastructure for their standardization, (c) prototyping cyber-infrastructures as both novel ways of forming academia and industry partnerships, and data infrastructures to accelerate data-driven adaption in FM for modular construction, and (d) synergistic activities with a two-year institution to train and educate FM workforce for the potential of FM and technologies evaluated.
The team argues that, while the evaluations of technologies will focus on the modular construction, the proposed technologies could make manufacturing industries more competitive, particularly heavy manufacturing industries that share similar challenges such as agricultural, mining, and ship building. The project will therefore enhance U.S. competitiveness in production, bolster economic growth, educate students, and influence workforce behavior towards efficiency and accuracy with the skills required for leadership in FM.