Preclinical leukemia chip platform improves evaluation of CAR T-Cell therapies
Researchers developed a bioengineered "leukemia chip" that combines human bone marrow structure with a functioning immune system to evaluate CAR T-cell therapies in real-time. The device models blood vessels, marrow cavity, and bone lining, enabling researchers to track immune cell behavior and predict treatment outcomes. Co-senior author Professor Weiqiang Chen explained: "We can now watch cancer treatments unfold as they would in a patient, but under completely controlled conditions without animal experimentation." The chip could enable personalized treatment selection.
