Iris Bibolli

Global Challenge: My mission is to deepen our understanding of the epigenetic mechanisms driving V(D)J recombination, in order to help pave the way for more effective and personalized immunotherapies.

Abstract:

My GLASS research project focused on understanding the epigenetic regulation of V(D)J recombination, a crucial process in the development of immune diversity. V(D)J recombination enables B and T cells to generate a wide array of antigen receptors through somatic gene rearrangement. While the enzymatic machinery driving this process is well characterized, emerging research highlights the importance of epigenetic modifications—such as histone methylation, acetylation, and chromatin remodeling—in determining the accessibility of gene segments for recombination. My project examined how these modifications guide the spatial and temporal control of recombination, particularly through the recruitment of the RAG complex to recombination-permissive regions.

I explored how disruptions to this regulation can lead to immunodeficiencies, leukemias, or autoimmune conditions and considered the therapeutic potential of manipulating epigenetic states to enhance immune function. This work also reflects broader questions in biomedical research about how genetic and epigenetic complexity can be harnessed to create precise, personalized treatments. As our understanding of chromatin biology deepens, the ability to design targeted immunotherapies improves—though access, affordability, and data diversity remain major challenges in applying these solutions globally. My project aligns with UN SDG 3: Good Health and Well-Being, focusing on how basic science can inform equitable healthcare solutions.

GLASS gave me the opportunity to explore this research within a global framework, pushing me to think about both the science and the systems surrounding it. My study abroad experiences in Abu Dhabi and Portugal helped me consider how cultural, economic, and structural factors shape access to emerging therapies. GLASS not only deepened my understanding of immune biology—it also strengthened my commitment to using science in service of public health and global equity.

Bio:

Iris Bibolli is an undergraduate student at the NYU Tandon School of Engineering, pursuing a Bachelor of Science in Biomolecular Science (Class of 2025). Passionate about the intersection of biology, engineering, and data science, Iris is committed to advancing research that improves human health through innovation and interdisciplinary collaboration.

As a GLASS Scholar, she conducts research on the epigenetic regulation of V(D)J recombination, aiming to better understand immune diversity and contribute to the development of personalized immunotherapies. Her work reflects a broader interest in translational science and the molecular mechanisms driving immune function.

Iris has pursued diverse research experiences across multiple labs. In the Margolis Lab, she studies gut-brain signaling via 5-HT4 receptors in the enteric nervous system using imaging and behavioral analysis. In the Truong Lab, she engineered immune cell differentiation using CRISPR-Cas9 and inducible gene circuits in iPSCs. At NYU Abu Dhabi, she investigated immune responses under microgravity using 3D cultures and flow cytometry, gaining a unique global perspective on biomedical research.

Outside of research, Iris serves as a Resident Assistant, where she fosters inclusive community and supports student well-being. She is also dedicated to STEM outreach and mentorship through programs like SOAR and TRIO Scholars, and has volunteered with underserved communities both locally and abroad.

Iris plans to pursue a career in biomedical research or translational medicine, where she can continue to explore complex biological systems and apply science to solve pressing global health challenges.