The Angel Cooler: Lung Transport Technology

Improving lung transport apparatus for organ longevity

A labelled image of a lung transport cooler with pipes for oxygen, multiple sensor and other equipment

Fall 2020 Update: The Angel Cooler will be expanding to include additional projects related to the COVID-19 pandemic.

Research

We have designed a prototype of the Angel Cooler. In this model, we successfully cooled oxygen and provided lung expansion in a test lung model to provide an ideal system for donor lung preservation and transportation.  All the components of the system are readily available and with minor design changes, this prototype could be modified into a commercial device. An initial patent search did not find any devices with this intent or mode of lung preservation. 

The team will research in developing a more functional and advanced prototype that will allow the cooling and monitoring of the airway pressures, oxygen concentration and airway temperature during transportation.  Also the device will need to have their own oxygen concentrator.

Goals

Current lung preservation practice requires external cooling of lungs. The bronchioles (small airway) are affected in transplant recipients that develop chronic lung allograft dysfunction (CLAD), which the most common and serious complication of lung transplantation.  “The Angel Cooler”, provides both oxygen and cooling directly to the airways (between 0-4OC) and external cooling to the surface of the lungs (Figure 1).  This system is connect to an standard endotracheal tube and a positive end expiratory pressure (PEEP) valve that provides a source of cold oxygen and will prevent atelectasis (lung collapse).

This project-based course will form research teams to design and prototype a functional Angel Cooler  which will be tested in animal experiments at the NYU Langone Lung Transplant Center.

Methods & Technologies

  • Computer-Aided Design
  • Rapid Prototyping
  • 3D Printing
  • Design Iteration 
  • Circuit Design & Fabrication
  • Data Collection & Feedback Control
  • Requirements Engineering
  • Health Standards & Certifications
  • Synthetic & Animal Experimentation

Subteams

  • Mechanical Team
  • Electrical Team
  • Medical Team

Areas of Interest

  • Mechanical Engineering
  • Electrical Engineering
  • Biomolecular Engineering
  • Chemical Engineering
  • Computer Engineering
  • Computer Science
  • Pre-Med
  • Business
  • Design
  • Any discipline with a passion for the project!

Partners

  • NYU Tandon School of Engineering
  • NYU Langone Health
  • NYU College of Arts and Sciences

Faculty Advisor

  • Luis Angel
  • Email: Luis.Angel@nyulangone.org
  • Amy Dunford
  • Email: amy.dunford@nyu.edu