Mary Cowman ,
Ph.D.

Founding Chair of the Department of Biomedical Engineering; Professor of Orthopaedic Surgery

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Research Interests: Bioanalytical and biophysical chemistry. Structure, function, and medical applications of the biomatrix surrounding cells, with special expertise in hyaluronan polysaccharide. Identification of biomarkers and bioactive fragments derived from extracellular matrix. Development of medical diagnostic assays. Discovery and development of biotherapeutics and biomaterials.

Columbia University College of Physicians and Surgeons
NIH Postdoctoral Fellow, Ophthalmology Research

Brandeis University
Postdoctoral Fellow, Biochemistry

Case Western Reserve University
Ph.D., Chemistry


Journal Articles

2010-present

  • Cowman, M.K., Shortt, C., Arora, S., Fu, Y., Villavieja, J., Rathore, J., Huang, X., Rakshit, T., Jung, G.I., and Kirsch, T. (2019) Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes” Inflammation,  PMID:31243649 https://doi.org/10.1007/s10753-019-01043-9
  • Tolg, C., Cowman, M. and Turley, E.A. (2018) "Mouse Mammary Gland Whole Mount Preparation and Analysis" Bio-protocol 8, e2915. https://doi.org/10.21769/BioProtoc.2915
  • Tolg, C., Cowman, M.K., Turley, E.A. (2018) “HA Isolation from Mammary Gland” Bio-protocol 8, e2865. https://doi.org/10.21769/BioProtoc.2865
  • Park, D.S.J., Regmi, S.C., Svystonyuk, D.A., Teng, G., Belke, D., Turnbull, J., Guzzardi, D.G., Kang, S., Cowman, M.K., Schmidt, T.A., Fedak, P.W.M. (2018) "Human Pericardial Proteoglycan 4 (Lubricin): Implications for Post-Cardiotomy Intrathoracic Adhesion Formation" J. Thorac Cardiovasc Surgery 156, 1598-1608. PMID:29859675 https://doi.org/10.1016/j.jtcvs.2018.03.170
  • Huang, X., Schmidt, T.A., Shortt, C., Arora, S., Asari, A., Kirsch, T., and Cowman, M.K. (2018) "A Competitive AlphaScreen Assay for Detection of Hyaluronan" Glycobiology 28, 137-147. PMID:29300896  https://doi.org/10.1093/glycob/cwx109
  • Tolg, C., Yuan, H., Flynn, S.M., Basu, K., Ma, J., Tse, K.C.K., Kowalska, B., Vulkanesku, D., Cowman, M.K., McCarthy, J.B., Turley, E.A. (2017) “Hyaluronan Modulates Growth Factor Induced Mammary Gland Branching in a Size Dependent Manner” Matrix Biology 63, 117-132. PMID:28232112 https://doi.org/10.1016/j.matbio.2017.02.003
  • Cowman, M.K. (2017) "Mutual Macromolecular Crowding as the Basis for Polymer Solution Non-ideality" Polym Adv Technol 28, 1000-1004. https://doi.org/10.1002/pat.3950
  • Cowman, M.K., Schmidt, T.A., Raghavan, P., and Stecco, A. (2015) “Viscoelastic Properties of Hyaluronan in Physiological Conditions” F1000Research 2015, 4:622. PMID:26594344 https://doi.org/10.12688/f1000research.6885.1
  • Schwertfeger, K.L., Cowman, M.K., Telmer, P., Turley, E.A., and McCarthy, J.B. (2015) "Hyaluronan, Inflammation and Breast Cancer Progression," Frontiers in Immunology 6:236. PMID:26106384 https://doi.org/10.3389/fimmu.2015.00236
  • Cowman, M.K., Lee, H-G., Schwertfeger, K.L., McCarthy, J.B., and Turley, E.A. (2015) "The Content and Size of Hyaluronan in Biological Fluids and Tissues", Frontiers in Immunology 6:261. PMID:26082778  https://doi.org/10.3389/fimmu.2015.00261
  • Yuan, H., Amin, R., Ye, X., de la Motte, C.A., and Cowman, M.K. (2015) "Determination of Hyaluronan Molecular Mass Distribution in Human Breast Milk" Anal. Biochem. 474, 78-88.  PMID:25579786 https://doi.org/10.1016/j.ab.2014.12.020
  • Ludwig, T., Cowman, M., Jay, G., Schmidt, T. (2014) "Effects of Concentration and Structure on Proteoglycan 4 Rheology and Interaction with Hyaluronan" Biorheology 51, 409-422. PMID:25818000  https://doi.org/10.3233/BIR-14037
  • Doudevski, I., Rostagno, A., Cowman, M., Liebmann, J., Ritch, R., and Ghiso, J. (2014) "Clusterin and complement activation in exfoliation glaucoma" Invest. Ophthalmol. Vis. Sci. 55, 2491-2499. PMID:24550356  https://doi.org/10.1167/iovs.13-12941
  • Hill, D.R., Rho, H.K., Kessler, S.P., Amin, R., Homer, C.R., McDonald, C., Cowman, M.K., and de la Motte, C.A. (2013) "Human milk hyaluronan enhances innate defense of the intestinal epithelium" J. Biol. Chem. 288, 29090-29104. PMID:23950179 https://doi.org/10.1074/jbc.M113.468629
  • Yuan, H., Tank, M., Alsofyani, A., Shah, N., Talati, N., LoBello, J.C., Kim, J.R., Oonuki, Y., de la Motte, C.A., and Cowman, M.K. (2013) "Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated HA binding protein" Glycobiology 23, 1270-1280. PMID:23964097  https://doi.org/10.1093/glycob/cwt064
  • Hill, D.R., Kessler, S.P., Rho, H.K., Cowman, M.K., and de la Motte, C.A. (2012) “Specific-sized Hyaluronan Fragments Promote Expression of Human b-Defensin 2 in Intestinal Epithelium” J. Biol. Chem. 287, 30610-31624. PMID:22761444 https://doi.org/10.1074/jbc.M112.356238
  • Tolg, C., Zalinska, E., Hamilton, S., McCulloch, L., Akentieva, N., Winnik, F., Savani, R., Bagli, D.J., Luyt, L.G., Amin, R., Cowman, M.K., McCarthy, J.B., and Turley, E.A. (2012) “A RHAMM mimetic peptide blocks hyaluronan fragment signaling and promotes skin excisional wound repair by reducing inflammation” Am. J. Pathology 181, 1250-1270. PMID:22889846 https://doi.org/10.1016/j.ajpath.2012.06.036
  • Cowman, M.K., Hernandez, M., Kim, J.R., Yuan, H., and Hu, Y. (2012) "Macromolecular Crowding in the Biomatrix", in Structure and Function of Biomatrix: Control of Cell Behavior and Gene Expression, E.A. Balazs, ed., Matrix Biology Institute, Edgewater, NJ, pp. 45-66.
  • Kwiecinski, J.J., Dorosz, S.G., Hill, T.E., Abubacker, S., Cowman, M.K., and Schmidt, T.A. (2011) "The Effect of Molecular Weight on Hyaluronan's Cartilage Boundary Lubricating Ability – Alone and in Combination with Proteoglycan 4" Osteoarthritis and Cartilage 19, 1356-1362. PMID:21683677 https://doi.org/10.1016/j.joca.2011.07.019
  • Bhilocha, S., Amin, R., Pandya, M., Yuan, H., Tank, M., LoBello, J., Shytuhina, A., Wang, W., Wisniewski, H-G., de la Motte, C.A., and Cowman, M.K. (2011) "Agarose and polyacrylamide gel electrophoresis methods for molecular weight analysis of 5-500 kDa HA" Anal. Biochem., 417, 41-49. doi: 10.1016/j.ab.2011.05.026 PMID:21684248 https://doi.org/10.1016/j.ab.2011.05.026
  • Cowman, M.K., Chen, C.C., Pandya, M., Yuan, H., Ramkishun, D., LoBello, J., Bhilocha, S., Russell-Puleri, S., Skendaj, E., Mijovic, J., and Jing, W. (2011) "Improved Agarose Gel Electrophoresis Method and Molecular Weight Calculation for High Molecular Weight Hyaluronan" Anal. Biochem., 417, 50-56. PMID:21683677  https://doi.org/10.1016/j.ab.2011.05.023

 

     

    Authored/Edited Books

    Books Edited:

    • Garg, H.G., Cowman, M.K., and Hales, C.A., eds. (2008) "Carbohydrate Chemistry, Biology, and Medical Applications", Elsevier, Amsterdam.
       

    Book Chapters:

    • Cowman, M.K. (2019) “Methods for Hyaluronan Molecular Mass Determination by Agarose Gel Electrophoresis” in Vigetti, D. and Theocharis, A., eds. The Extracellular Matrix: Methods and Protocols, Methods in Molecular Biology, Vol. 1952, Springer Science + Business Media, New York, pp 91-102. PMID:30825168  https://doi.org/10.1007/978-1-4939-9133-4_8
    • Cowman, M.K. (2017) “Hyaluronan and Hyaluronan Fragments”, in Advances in Carbohydrate Chemistry and Biochemistry, D.C. Baker, ed., Elsevier/Academic Press, Burlington, Vol. 74, pp 1-59. PMID:29173725  https://doi.org/10.1016/bs.accb.2017.10.001

     


    • Director, Biomatrix Research Center, 2015-2016
    • Visiting Professor, Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, 2014-present
    • Director, Westchester subsection, American Chemical Society, 2006-2010
    • Director-at Large, New York Section, American Chemical Society, 2007-2008
    • Member of International Society for Hyaluronan Sciences, American Chemical Society, Biophysical Society, Society for Glycobiology, American Society for Matrix Biology, Orthopaedic Research Society, American Association of Pharmaceutical Scientists, New York Academy of Sciences.
    • Scientific Program and Planning Committees: "Hyaluronan 2000", "MMC-9" (Macromolecule-Metal Complexes 2001), "Hyaluronan 2003", “Hyaluronan 2007”, "Hyaluronan 2013", "Hyaluronan 2015", Hyaluronan 2017.
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    • Founding Member, former Treasurer, Secretary, Trustee, and current President, International Society for Hyaluronan Sciences, 2004-present
    • Distinguished Scientist Award, Westchester Chemical Society, 2007
    • Distinguished Teacher Award, Polytechnic University, 2006
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    Biocompatible materials containing stable complexes of TSG-6 and

    US Patent No. 8,093,365. Issued January 10, 2012.

    Biocompatible materials containing stable complexes of TSG-6 and , (US Patent 8,420,601 (divisional). Issued April 16, 2013)

    Nanocomposite Hyaluronic Acid-Clay Based Hydrogels., (US Patent 8,367,117. Issued February 5, 2013. )

    Compositions and Methods for Cartilage Defect Repair using a RHAMM - Mimetic Pepide , (US Patent 10, 449, 229. Issued October 22, 2019)