Jef D. Boeke
Professor of Biochemistry and Molecular Pharmacology
Professor of Biomedical Engineering
- Director of the Institute of Systems Genetics
- Member NAS, AAA&S
The laboratory of Professor Jef Boeke is well known for foundational work on mechanistic and genomic aspects of retro-transposition in both yeast and mammalian systems. In addition, the Boeke lab is heavily involved in the development of novel technologies in genetics, genomics and synthetic biology. His group uses yeast as a platform for exploring the construction of fully synthetic chromosomes for practical and theoretical studies. They have congregated an international consortium called SC2.0 to rewrite and synthesize the first eukaryotic organism, Saccharomyces cerevisiae. We project complete synthesis and “debugging” of the entire genome by the end of 2020.
Research Interests: cancer, computational biology, genome integrity, genomics, microbiology, pharmacology, stem cell biology, systems biology, yeast, retrotransposon