New Delivery Vehicle Developed for Gene Therapy

Scientists at the Polytechnic Institute of New York University (NYU-Poly) and the NYU College of Dentistry (NYUCD) report the development of a carrier that is five times more efficient in delivering DNA into cells than today's commercial reagent vector delivery methods. The new system is a peptide-polymer hybrid, assembled from two separate, less effective vectors that are used to carry DNA into cells.

Results of their study, “Long Term Efficient Gene Delivery Using Polyethylenimine with Modified Tat Peptide,” were published in Biomaterials. The findings were the result of a collaborative research project conducted by Seiichi Yamano, Ph.D., at NYUCD and Jin Montclare, Ph.D., at NYU-Poly. The outcome of the study could help researchers better understand gene function and ultimately improve gene therapy, according to Drs. Yamano and Montclare.

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