Perineural Invasion and Oral Cancer

Lecture / Panel
Open to the Public

Perineural Invasion and Oral Cancer


Yi Ye, PhD, MS, MBA
Assistant Professor
Dept. of Oral and Maxillofacial Surgery &Pathobiology Medicine
NYU College of Dentristy


Dr. Ye’s laboratory focuses on understanding how peripheral nerves interact with the oral cancer microenvironment to mediate pain as well as tumor progression. To decipher shared molecular and cellular mechanisms underlying cancer progression and pain, her lab combines 2-D and 3-D cell culture, calcium imaging, electrophysiology, microscopy, molecular and genetic mani-pulations, pharmacology, and behavioral testing in experimental models of oral cancer pain. Understanding the overlapping mechanisms responsible for oral cancer progression and pain may lay the foundation for the development of novel therapeutics for cancer and cancer pain. Her pursuit of research on pain blossomed from her PhD dissertation work investigating how primary afferent neurons respond to thermal and mechanical stimuli during the development of inflammation and in the context of inflammation.

Dr. Yi Ye received her PhD in neuroscience the University of Wyoming and undertook postdoctoral training at the University of California San Francisco and NYU where she inves-tigated peripheral mechanisms of oral cancer pain. To enhance her skills in translational research and research management, she earned a Master’s degree in Clinical Research as well as a Master’s degree in Business Administration at NYU. In 2015, Dr. Ye was appointed to a faculty position at NYU Dentistry. Her research has been funded by the National Institutes of Health and various scientific research foundations. Dr. Ye was honored with the Young Investigator Award from the International Association for the Study of Pain (IASP), the Rita Allen Foundation Award in Pain, the KL2 scholar award from NIH-NYU Clinical and Translational Science Institute (CTSI).


Yi Ye
Inhibition of EGFR signaling in oral cancer pain: Representative anti-EGFR immunoreactivity (Green) in trigeminal (TG) sections (12 μm) from a mouse with retrograde labeling from the tongue (DiI, Red). DAPI was used to identify nuclei (Blue). More than 90% of all DiI-labeled neurons overlapped (Merge, Yellow) with EGFR immunoreactivity (×20 magnification).