Translating Molecular Bioengineering from the Lab to the Patient

Seminar / Lecture
For NYU Community

Ashutosh Chilkoti


Ashutosh Chilkoti

Department of Biomedical Engineering Duke University


This talk will highlight recent work from my laboratory that illustrates the clinical translation of molecular bio- engineering technologies for point-of-care clinical diagnostics, drug delivery, and regenerative medicine. In the first example, I will describe a point-of-care diagnostic —the D4 assay — that we have developed, in which all reagents are printed and stored on a “non-fouling”—protein and cell resistant—polymer brush. The D4 assay
has a speed and sensitivity that is as good or better than commercially available point-of-care tests and is far sim- pler, cheaper more rugged, and does not require a cold-chain. In a second example in the area of tissue engineer- ing/regenerative medicine, I will discuss how we have used ELPs as a template to encode higher order, hierarchi- cal self-assembly into macroscopic biomaterials by modulating the degree of order in these intrinsically disor- dered polymers, leading to materials that are soluble at room temperature but upon injection subcutaneously —or elsewhere in the body— self-assemble into a physically crosslinked material with interconnected pores. These ma- terials spontaneously vascularize, exhibit minimal inflammation, and show excellent tissue integration, and these properties suggest that they may be useful for regenerative medicine.