Molecular Biomimetics: Genetically-Engineered Peptide-Guided Technology & Medicine
Materials Science & Engineering, Chemical Engineering, and Oral Health Sciences GEMSEC, University of Washington
Predictably interfacing biomolecules with technological solids is the key for drug delivery, enzyme im- mobilization, implant biofunctionalization, and biochemical-sensors as well as direct interrogation of cell behavior and remineralization in tissue repair. Highly specific interactions controlled by proteins facilitate explicit recognition of minerals and formation of intricate supramolecular architectures in na- ture. Mimicking natural proteins, engineered short polypeptides, aka GEPIs, are ubiquitous molecular tools in addressable synthesis and functionalization of solid interfaces. Simplicity of peptide sequences and functional domains offer latent means for tailoring and interrogating intermolecular forces through deep-mutations and predictive computational biology for tailored molecular recognition and signal transduction. At the convergence of many science and technology fields, and using biocombinatorially selected and nano/bio-informatically-designed peptides, our Lab has been leading the genetic regulation of molecular interactions at solid interfaces in biosynthesis, assembly, and organized molecular architec- tures with potent utility in technological implementations as well as in molecular-med- icine. Starting with a discussion of the fun- damentals lessons from biology, this talk will review the wide range of practical utili- ty of GEPIs, all under biologically viable conditions, encompassing many the devel- opments in materials and device fabrication during the last 2 decades, including bio- mimetic dental repair using peptide-based prototype formulations and SAP/SLAM sys- tem, self-assembled peptide/single layer atomic solids, in applications of, e.g., FET- based bionanosensors, with a recent strate- gies merging molecular biomimetics with data science and recently emerging special- ized ML/AI algorithms. Funded by NSF-MGI and Amazon-Catalyst programs.
- 10:30 Refreshments
- 10:45–12:00 Talk