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Stephen Arnold

Stephen Arnold

University Professor

Physics and Chemistry

Journal Articles

    FOR ALL PUBLICATIONS VISIT www.mp3l.org
  • V.R. Dantham, S. Holler, C. Barbre, D. Keng, V. Kolchenko, S. Arnold,"Label-free Dectection of Single Protein using  a Nanoplasmonic-Photonic Hybrid Microcavity", Nano Lett. 13, 3347-3351 (2013).
  • I.W. Selesnick, S. Arnold, V.R. Dantham, "Polynomial Smoothing of Time Series with Additive Step Discontinuities", IEEE Trans. Signal Pross. 60, 6305-6318(2012).
  • S. Arnold, V.R. Dantham, C. Barbre, B.A. Garetz, "Periodic palsmonic enhancing epitopes on a whisperiong gallery mode biosensor", Opt. Express 20, 26147-26159(2012).
  • V.R. Dantham, S. Holler, Z. Wan, V. Kolchenko, S. Arnold, "Taking Whispering Gallery Mode Single Virus Detection and Sizing to the Limit" , Appl. Phys. Lett. 101, 043704(2012).
  • David Ehre, Ke Fang, Janice E. Aber, Stephen Arnold,Michael D. Ward, and Bruce A. Garetz, "Polymorphism in Containerless Crystallization", Cryst. Growth Des. DOI: 10.1021/cg200824h
  • S. I. Shopova, R. Rajmangal, S. Holler, S. Arnold, "Plasmonic Enhancement of a Whispering Gallery Mode Biosenor for Single Nanoparticle Detection", Applied Physics Letters 98, 243104(2011).
  • S. I. Shopova, R. Rajmangal, Y. Nishida, S. Arnold, “Ultra-sensitive Nanoparticle Detection using a Portable Whispering Gallery Mode Biosensor driven by a PPLN doubled DFB laser”, Rev. Scientific Instruments 81, 103110 (2010).
  • Y. Sun, S.I. Shopova, C.S. Wu, S. Arnold, X. Fan, “Optofluidic FRET lasers via DNA scaffolds”, Proc. National Academy of Sciences 107, 15039-16042(2010).
  • S. Arnold, S.I. Shopova, and S. Holler, "Whispering Gallery Mode Bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism, Optics Express 18, 281-287(2010). 
  •  I. Teraoka, and S. Arnold, "Resonance shifts of counter-propagating whispering-gallery modes: degenerate perturbation theory and application to resonator sensors with axial symmetry nanoparticle detection in biosensing", J. Opt. Soc. Am. B, 26, 1321 -1329 (2009).
  • S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky, and F. Vollmer,
"Whispering gallery mode carousel – a photonic mechanism for enhanced nanoparticle detection in biosensing", Opt. Express, 17, 6230-6238 (2009).
  • F. Vollmer, S. Arnold, and D. Keng, “Single virus detection from the reactive shift of a whispering-gallery mode”,
       Proc. National Academy of Sciences, 105, 20701-20704 (2008).
  • I. Teraoka and S. Arnold, “Variational principle in whispering gallery mode sensor responses”, J. Opt. Soc. Am. B, 25, 1038 -1045 (2008).
  • F. Vollmer and S. Arnold, "Whispering-gallery-mode biosensing: label-free detection down to single molecules", Nature Methods, 5, 591-596 (2008).
  • S. Arnold, R. Ramjit, D. Keng, V. Kolchenko and I. Teraoka, “MicroParticle photophysics illuminates viral bio-sensing”,
 FARADAY DISCUSSIONS 137, 65-83 (2008).
  • I. Teraoka and S. Arnold, “Estimation of surface density of molecules adsorbed on a whispering gallery mode resonator: Utility of isotropic polarizability”, J. of Appl. Phys. 102, 076109 (2007).
  • H. Ren, F. Vollmer, S. Arnold and A. Libchaber, “High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria”,
 Opt. Express 15, 17410 (2007).
  • D. Keng, S. R. McAnanama, I. Teraoka, and S. Arnold, “Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion”,  Appl. Phys. Lett. 91, 103902 (2007).
  • M. Noto, D. Keng, I. Teraoka, and S. Arnold, “Detection of Protein Orientation on the Silica Microsphere Surface using
Transverse Electric/Transverse Magnetic Whispering Gallery Modes”, Bio. Phys. J., 92, 4466-4472 (2007).
  • I. Teraoka, and S. Arnold, “Coupled whispering gallery modes in a multilayer-coated microsphere”, Opt. Lett. 32, 1147-1149 (2007).
  • I. Teraoka, and S. Arnold, “Whispering-gallery modes in a microsphere coated with a high-refractive index layer:
polarization-dependent sensitivity enhancement of the resonance-shift sensor and TE–TM resonance matching”,
 J. Opt. Soc. Am. B, 24, 653 (2007).
  • I. Teraoka, and S. Arnold, “Dielectric property of particles at interface in random sequential adsorption and its application to whispering gallery mode resonance-shift sensors”, J. of Appl. Phys. 101, 023505 (2007).
  • O. Gaathon, J. Culic-Viskota, M. Mihnev, I. Teraoka and S. Arnold, “Enhancing sensitivity of a whispering gallery mode biosensor by subwavelength confinement”, Appl. Phys. Lett. 89, 223901 (2006).
  • G. Guan, S. Arnold and M. V. Otugen, “Temperature measurements using a microoptical sensor based on whispering gallery modes”, AIAA JOURNAL, Vol. 44, 2385 (2006).
  • I. Teraoka and S. Arnold, “Enhancing the sensitivity of a whispering-gallery mode microsphere sensor by a high-refractive-index surface layer”, J. Opt. Soc. Am.B, 23, 1434 (2006).
  • I. Teraoka and S. Arnold, “Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications”, J. Opt. Soc. Am.B, 23, 1381 (2006).
  • M. Noto, M. Khoshsima, D. Keng, I. Teraoka, V. Kolchenko, and S. Arnold, “Molecular weight dependence of a whispering gallery mode biosensor”,
 Appl. Phys. Lett. 87, 223901 (2005).
  • M. Noto, F. Vollmer, D. Keng, I. Teraoka, S. Arnold, “Nanolayer characterization through wavelength multiplexing
of a microsphere resonator”,
 Opt. Lett. 30, No. 5 (2005).
  • J. Aber, S. Arnold, B. Garetz, “Strong dc Electric Field Applied to Supersaturated Aqueous 
Glycine Solution Induces Nucleation of the gamma Polymorph”, Physical Review Letters 94,145503 (2005).
  • F. Vollmer, S. Arnold, D. Braun, I. Teraoka, A. Libchaber, “Multiplexed DNA Quantification by Spectroscopic Shift of Two Microsphere Cavities” Bio. Phys. J., 85, 1974-1979, (2003).
  • I. Teraoka, S. Arnold, F. Vollmer, “Perturbation Approach to Resonance Shift of Whispering Gallery Modes
in Dielectric Microspheres as a Probe of a Surrounding Medium”, J. Opt. Soc. B 20, 1937-1946 (2003).
  • S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, F. Vollmer, “Shift of Whispering Gallery Modes in Microspheres by Protein Adsorption”, Opt. Lett. 28, 272-274 (2003).

Education

City University of New York, Class of 1970

Doctor of Philosophy, Physics

University of Toledo, Class of 1964

Bachelor of Science, Engineering Physics

Experience

Harvard

Visiting Scholar

From: January 2013 to May 2013

Polytechnic Institute of NYU

Director, Othmer Institute for Interdisciplinary Research

From: July 2003 to July 2005

University of Tokyo

Visiting Scholar

From: February 1997 to May 1997

The Aerospace Corp.

Member of Technical Staff

From: February 1990 to May 1990

California Institute of Technology

Chevron Distinguished Visiting Professor

From: February 1985 to May 1985

Ecole Normale Superieure, Paris 20

Scientist

From: March 1972 to September 1973

Patents

Detecting and/or Measuring Substance based on Resonance Shifts..., (Utility)

No. 7,491,491 Issued-February 17, 2009, Filed- Mar 12, 2002

In Recent School News

Single Molecule Detection of a Cancer Biomarker

Posted September 12th, 2013

Single Molecule Detection of a Cancer Biomarker

Posted September 4th, 2013

New Label-Free Technique Detects Single Proteins; May Open New Future in Clinical Diagnostics

Posted August 9th, 2013

Sensor detects incredibly small cancer marker

Posted August 5th, 2013

Nanoenhanced Biosensor Detects Single Proteins

Posted August 5th, 2013

Awards + Distinctions

External:

Fellow-American Physical Society (1990-present)

Fellow-Optical Society of America (1988-present)

Fellow-Alfred P. Sloan Foundation (1981)

Visiting Scholar, Harvard (Spring, 2013)

John J. Turin Award for Outstanding Career Accomplishments in Physics, University of Toledo(2000),

Visiting Scholar University of Tokyo (Spring, 1997)

Outstanding Publication Award, Oak Ridge National Lab (1994)

Sigma Xi Award for Distinguished Scientific Research (1986)

Chevron Distinguished Visiting Prof. CAL-TECH (Spring, 1985)

 

Internal:

Othmer-Potts Senior Faculty Fellow (2001-Present)

University Professor (1996-Present)

Thomas Potts Professor of Physics (1985-Present)

Affiliations

American Physical Society (Fellow) Optical Society of America (Fellow) Tau Beta Pi

Research Interests

Microparticle Photophysics

Whispering Gallery Mode Biosensing

Organic Molecular Crystals

General / Collaborative Research

Optical Biosensors with I. Teraoka (CBS) Light Induced Nucleation with B. Garetz (CBS) Nano-particle Transport in Fluids by Photons with W. Zurawsky (CBE) Micro-sensors with V.T. Otugen (ME) Micro-Photonics with G. Griffel (ECE) MicroParticle Enhanced Energy Transfer with L.M. Folan (Physics)