Mary K. Cowman

Mary K. Cowman

Associate Dean for Bioengineering and Professor of Biochemistry and Bioengineering

Chemical and Biomolecular Engineering

Journal Articles

  • Cowman, M.K., Lee, H-G., Schwertfeger, K.L., McCarthy, J.B., and Turley, E.A. (2015) "The Content and Size of Hyaluronan in Biological Fluids and Tissues", Frontiers in Immunology 6:261
  • Schwertfeger, K.L., Cowman, M.K., Telmer, P., Turley, E.A., and McCarthy, J.B. (2015) "Hyaluronan, Inflammation and Breast Cancer Progression," Frontiers in Immunology 6:236
  • Yuan, H., Amin, R., Ye, X., de la Motte, C.A., and Cowman, M.K. (2015) "Determination of Hyaluronan Molecular Mass Distribution in Human Breast Milk" Anal. Biochem. 474, 78-88. 
  • Ludwig, T., Cowman, M., Jay, G., Schmidt, T. (2014) "Effects of Concentration and Structure on Proteoglycan 4 Rheology and Interaction with Hyaluronan" Biorheology 51, 409-422.
  • Cowman, M.K., Lee, H-G., Schwertfeger, K.L., McCarthy, J.B., and Turley, E.A. (2015, in press) "The Content and Size of Hyaluronan in Biological Fluids and Tissues", Frontiers in Immunology
  • Schwertfeger, K.L., Cowman, M.K., Telmer, P., Turley, E.A., and McCarthy, J.B. (2015, in press) "Hyaluronan, Inflammation and Breast Cancer Progression," Frontiers in Immunology
  • Ludwig, T., Cowman, M., Jay, G., Schmidt, T. (2015) "Effects of Concentration and Structure on Proteoglycan 4 Rheology and Interaction with Hyaluronan" Biorheology 51, 409-422.
  • Yuan, H., Amin, R., Ye, X., de la Motte, C.A., and Cowman, M.K. (2015) "Determination of Hyaluronan Molecular Mass Distribution in Human Breast Milk" Anal. Biochem. 474, 78-88.  PMID25579786
  • Doudevski, I., Rostagno, A., Cowman, M., Liebmann, J., Ritch, R., and Ghiso, J. (2014) "Clusterin and complement activation in exfoliation glaucoma" Invest. Ophthalmol. Vis. Sci. 55, 2491-2499. PMID24550356
  • Hill, D.R., Rho, H.K., Kessler, S.P., Amin, R., Homer, C.R., McDonald, C., Cowman, M.K., and de la Motte, C.A. (2013) "Human milk hyaluronan enhances innate defense of the intestinal epithelium" J. Biol. Chem. 288, 29090-29104. PMID23950179
  • Yuan, H., Tank, M., Alsofyani, A., Shah, N., Talati, N., LoBello, J.C., Kim, J.R., Oonuki, Y., de la Motte, C.A., and Cowman, M.K. (2013) "Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated HA binding protein" Glycobiology 23, 1270-1280. PMID23964097
  • Hill, D.R., Kessler, S.P., Rho, H.K., Cowman, M.K., and de la Motte, C.A. (2012) “Specific-sized Hyaluronan Fragments Promote Expression of Human β-Defensin 2 in Intestinal Epithelium” J. Biol. Chem. 287, 30610-31624. PMID22761444
  • Tolg, C., Zalinska, E., Hamilton, S., McCulloch, L., Akentieva, N., Winnik, F., Savani, R., Bagli, D.J., Luyt, L.G., Amin, R., Cowman, M.K., McCarthy, J.B., and Turley, E.A. (2012) “A RHAMM mimetic peptide blocks hyaluronan fragment signaling and promotes skin excisional wound repair by reducing inflammation” Am. J. Pathology 181, 1250-1270. PMID22889846
  • Cowman, M.K., Hernandez, M., Kim, J.R., Yuan, H., and Hu, Y. (2012) "Macromolecular Crowding in the Biomatrix", in Structure and Function of Biomatrix: Control of Cell Behavior and Gene Expression, E.A. Balazs, ed., Matrix Biology Institute, Edgewater, NJ, pp. 45-66.
  • Kwiecinski, J.J., Dorosz, S.G., Hill, T.E., Abubacker, S., Cowman, M.K., and Schmidt, T.A. (2011) "The Effect of Molecular Weight on Hyaluronan's Cartilage Boundary Lubricating Ability – Alone and in Combination with Proteoglycan 4"  Osteoarthritis and Cartilage 19, 1356-1362. PMID21683677
  • Bhilocha, S., Amin, R., Pandya, M., Yuan, H., Tank, M., LoBello, J., Shytuhina, A., Wang, W., Wisniewski, H-G., de la Motte, C.A., and Cowman, M.K. (2011) "Agarose and polyacrylamide gel electrophoresis methods for molecular weight analysis of 5-500 kDa HA" Anal. Biochem., 417, 41-49. doi: 10.1016/j.ab.2011.05.026  PMID21684248
  • Cowman, M.K., Chen, C.C., Pandya, M., Yuan, H., Ramkishun, D., LoBello, J., Bhilocha, S., Russell-Puleri, S., Skendaj, E., Mijovic, J., and Jing, W. (2011) "Improved Agarose Gel Electrophoresis Method and Molecular Weight Calculation for High Molecular Weight Hyaluronan" Anal. Biochem., 417, 50-56. doi: 10.1016/j.ab.2011.05.023 PMID21683677

Education

Case Western Reserve University

Ph.D., Chemistry

Brandeis University

Postdoctoral Fellow, Biochemistry

Columbia University College of Physicians and Surgeons

NIH Postdoctoral Fellow, Ophthalmology Research

Patents

Nanocomposite Hyaluronic Acid-Clay Based Hydrogels., (US Patent 8,367,117. Issued February 5, 2013. )

Biocompatible materials containing stable complexes of TSG-6 and , (US Patent 8,420,601 (divisional). Issued April 16, 2013)

Biocompatible materials containing stable complexes of TSG-6 and , (US Patent 8,093,365. Issued January 10, 2012)

Authored + Edited Books

Books Edited:

  • Garg, H.G., Cowman, M.K., and Hales, C.A., eds. (2008) "Carbohydrate Chemistry, Biology, and Medical Applications", Elsevier, Amsterdam.
     

Book Chapters:

  • Fasman, G.D. and Cowman, M.K. (1978). "Interpretation of Chromatin Structure by Circular Dichroism Analysis."  in The Cell Nucleus, Vol. 5, H. Busch, ed., Academic Press, New York, pp.55-97.
  • Cowman, M.K. and Mendichi, R. (2004) “Methods for Determination of Hyaluronan Molecular Weight” in Chemistry and Biology of Hyaluronan, H.G. Garg and C.A. Hales, eds., Elsevier Press, Amsterdam, pp. 41-69.

In Recent School News

A Storied Life

Awards + Distinctions

  • Founding Member, former Treasurer, Secretary, Trustee, and current President-Elect, International Society for Hyaluronan Sciences, 2004-present
  • Distinguished Scientist Award, Westchester Chemical Society, 2007
  • Distinguished Teacher Award, Polytechnic University, 2006

Affiliations

  • Director, Biomatrix Research Center, 2015-present
  • Visiting Professor, Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, 2014-present
  • Director, Westchester subsection, American Chemical Society, 2006-2010
  • Director-at Large, New York Section, American Chemical Society, 2007-2008
  • Member of American Chemical Society, Biophysical Society, Society for Glycobiology, American Association of Pharmaceutical Scientists, New York Academy of Sciences, Sigma Xi.
  • Scientific Program and Planning Committees: "Hyaluronan 2000", "MMC-9" (Macromolecule-Metal Complexes 2001), "Hyaluronan 2003", “Hyaluronan 2007”, "Hyaluronan 2013", "Hyaluronan 2015"

Research Interests

Bioanalytical and buiphysical chemistry. Structure, function, and medical applications of the biomatrix surrounding cells, with special expertise in hyaluronan polysaccharide. Identification of biomarkers and bioactive fragments derived from extracellular matrix. Development of medical diagnostic assays. Discovery and devlopment of biotherapeutics and biomaterials.