Jin Ryoun Kim

Jin Ryoun Kim

Associate Professor

Chemical and Biomolecular Engineering


Jin Ryoun Kim is performing research in the creation of novel proteins for complex functionality such as the design of a protein sensor for detection of toxic molecules in neurodegenerative diseases and the development of a highly-stable enzyme that can be used in industry. His work has been recognized as significant by prestigious scientific societies and magazines.

He joined the faculty of Polytechnic Institute of NYU in 2006 in the Department of Chemical and Biological Engineering.

He earned a Bachelor of Science (with honors) and a Master of Science in Chemical Engineering from Seoul National University in 1997 and 1999, respectively and a PhD in Chemical and Biological Engineering from the University of Wisconsin-Madison in 2004.

Kim has authored manyl journal articles and patents and is a member of the American Institute of Chemical Engineering, the American Chemical Society, the Protein Society, and the New York Academy of Sciences.

He is the recipient of the New Investigator Award from the Alzheimer’s Association (2009-2011), the Wechsler Award for Excellence (2009) and the Jacobs Excellence in Education Award (2013). He currently serves as an associate editor of the Korean Journal of Chemical Engineering.

Journal Articles

  • Vandan Shah, Brennal Pierre, Tamari Kirtadze, Seung Shin, Jin Ryoun Kim, "Stabilization of Bacillus circulans xylanase by combinatorial insertional fusionto a thermophilic host protein", Protein Engineering, Design & Selection, in press (2017)
  • Abhijit N. Shirke, An Su, J. Andrew Jones, Glenn L. Butterfoss, Mattheos A.G. Koffas, Jin Ryoun Kim, Richard A. Gross, "Comparative thermal inactivation analysis of Aspergillus oryzae and Thiellavia terrestris cutinase: Role of glycosylation.", Biotechnology Bioengineering, 114:63-73 (2017)
  • Vandan Shah, Jin Ryoun Kim, "Transposon for protein engineering", Mobile Genetic Elements, 6:6 (2016)
  • Brennal Pierre, Jason W. Labonte, Tina Xiong, Edwin Aoraha, Asher Williams, Vandan Shah, Edward Chau, Kazi Yasin Helal, Jeffrey Gray, Jin Ryoun Kim, "Molecular determinants for protein stabilization by insertional-fusion to a thermophilic host protein", ChemBioChem, 16:2392-2402 (2015)
  • Edwin Aoraha, Jason Candreva and Jin Ryoun Kim, "Engineering of a peptide probe for β-amyloid aggregates", Molecular Biosystems, 11:2281-2289 (2015)
  • Brennal Pierre, Vandan Shah, Jenny Xiao and Jin Ryoun Kim, "Construction of a random circular permutation library using an engineered transposon", Analytical Biochemistry, 474:16-24 (2015)
  • Keeshan Williams, Chung-Sei Kim, Jin Ryoun Kim and Rastislav Levicky, "Multimodal electrochemical sensing of transcription factor-operator complexes.", Analyst, 139:1463-71 (2014)
  • Michael Hernandez, Yang Hu and Jin Ryoun Kim, "A conformation-switching fluoresent protein probe for detection of alpha synuclein oligomers", Chemical Communications, 49:10712-4 (2013)
  • Han Yuan, Mihir Tank, Abeer Alsofyani, Naman Shah, Nishant Talati, Jaclyn C LoBello, Jin Ryoun Kim, Yoji Oonuki, Carol A de la Motte and Mary K Cowman, "Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein, Glycobiology, 23:1270-80 (2013)
  • Vandan Shah, Brennal Pierre and Jin Ryoun Kim, "Facile construction of a random protein domain insertion library using an engineered transposon", Analytical Biochemistry,  432:97-102 (2013)
  • Ahra Ko and Jin Ryoun Kim, "Effects of intramolecular distance between amyloidogenic domains on amyloid aggregation", International Journal of Molecular Sciences, 13: 12169-12181 (invited contribution) (2012)
  • Mary K Cowman, Michael Hernandez, Jin Ryoun Kim, Han Yuan and Yang Hu, "Macromolecular Crowding in the Biomatrix", Structure and Function of Biomatrix: Control of Cell Function and Gene Expression, edited by E.A. Balazs and M. Hargittai, Matrix Biology Institute in Edgewater, NJ, in press (2012)
  • Yang Hu, Baihao Su, HeQiu Zheng and Jin Ryoun Kim, "A peptide probe for detection of various beta-amyloid oligomers", Molecular BioSystems, 8:2741-2752 (2012)
  • Yang Hu, HeQiu Zheng, Baihao Su and Jin Ryoun Kim, "Modulation of beta-amyloid aggregation by engineering the sequence connecting beta-strand forming domains", Biochimica et Biophysica Acta - Proteins and Proteomics, 1824:1069-1079 (2012)
  • Michael Hernandez, Sofia Golbert, Li Guo Zhang and Jin Ryoun Kim, "Creation of aggregation-defective alpha synuclein variants by engineering the sequence connecting beta strand forming domains", ChemBioChem, 12:2630-2639 (2011)
  • Joon Ho Ahn, Yang Hu, Michael Hernandez and Jin Ryoun Kim, "Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers", Biochemical and Biophysical Research Communications, 414:79-83 (2011)
  • Jung-Eun Cho and Jin Ryoun Kim, "Recent approaches targeting beta-amyloid for therapeutic intervention of Alzheimer's disease", Recent Patents on CNS Drug Discovery (invited review), 6:222-233 (2011)
  • Brennal Pierre, Tina Xiong, Leonie Hayles, Visweswara Reddy Guntaka, and Jin Ryoun Kim, "Stability of a guest protein depends on stability of a host protein in insertional fusion", Biotechnology & Bioengineering, 108(5):1011-1020 (2011)
  • Yang Hu, Baihao Su, Chung-Sei Kim, Michael Hernandez, Agueda Rostagno, Jorge Ghiso, and Jin Ryoun Kim, "A strategy for designing a peptide probe for detection of beta-amyloid oligomers", ChemBioChem,11: 2409-2418 (2010)
  • Chung-Sei Kim, Brennal Pierre, Marc Ostermeier, Loren L. Looger and Jin Ryoun Kim, "Enzyme stabilization by domain insertion into a thermophilic protein", Protein Engineering, Design & Selection, 22:615-623 (2009)
  • Sachin Khapli, Jin Ryoun Kim, Jin Kim Montclare, Rastislav Levicky, Maurizio Porfiri and Stavroula Sofou, "Frozen Cyclohexane-in-Water Emulsion as a Sacrificial Template for the Synthesis of Multilayered Polyelectrolyte Microcapsules", Langmuir, 25: 9728?733 (2009)
  • Jing Liang, Jin Ryoun Kim, James T. Boock, Thomas, J. Mansell, Marc Ostermeier, "Ligand binding and allostery can emerge simultaneously", Protein Sci. 16: 929-937 (2007).
  • Jin Ryoun Kim, Todd J. Gibson, Regina M. Murphy, “Predicting solvent and aggregation effects of peptides using group contribution calculations”, Biotechnoogy Progress, 22:605-608 (2006). 
  • Jin Ryoun Kim, Marc Ostermeier, “Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase”, Archives of Biochemistry and Biophysics, 446:44-51 (2006).



Johns Hopkins University, 2006

Postdoctoral Fellow,

University of Wisconsin-Madison, 2004

Doctor of Philosophy, Chemical and Biological Engineering

Seoul National University, 1999

Master of Science, Chemical Engineering

Seoul National University, 1997

Bachelor of Science, Chemical Engineering

Research Interests

Protein engineering for therapeutic purpose

Protein folding and stability

Creation of protein-based biosensor

Design of an in situ molecular sensor for different aggregates species generated in Alzheimer's and Parkinson's disease

Characterization of protein aggregation

Development of mutation-free protein thermostabilization methods


NSF BBBE, NSF Biosensing, NSF MRI, Alzheimer's association, ()