Alesha B Castillo, PhD

Alesha B Castillo, PhD

Assistant Professor

Mechanical and Aerospace Engineering & Orthopaedic Surgery

Biography

Dr. Castillo's research focuses on interactions between mechanobiological cues and musculoskeletal systems, with consideration given at the molecular, cellular, and tissue levels. Specific areas of interest include musculoskeletal biomechanics, mechanobiology, regeneration, and stem cell biology, with work grounded in engineering tools and analyses, state-of-the-art cell and molecular biology, and translational medicine.

Journal Articles

Selected Publications:

Castillo AB, Blundo JT, Chen JC, Lee KL, Yereddi NR, Jang E, Kumar S, Tang WJ, Zarrin S, Jacobs CR. Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One. 2012;7(9):e43291. PubMed PMID: 23028449; PubMed Central PMCID: PMC3448625.

Leucht P, Temiyasathit S, Russell A, Argüello J, Jacobs CR, Helms JA, Castillo AB. CXCR4 antagonism attenuates load-induced periosteal bone formation in mice. J Orthop Res. 2013 Nov;31(11):1828-38. PubMed PMID: 23881789.

Castillo AB, Triplett JW, Pavalko FM, Turner CH. Estrogen receptor-β regulates mechanical signaling in primary osteoblasts. Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E937-44. PubMed PMID: 24619882; PubMed Central PMCID: PMC3989741.

Norman SC, Wagner DW, Beaupre GS, Castillo AB. Comparison of three methods of calculating strain in the mouse ulna in exogenous loading studies. J Biomech. 2015 Jan 2;48(1):53-8. PubMed PMID: 25443882.

Other Publications

Robling AR, Castillo AB, Turner CH. (2006) Biomechanical and Molecular Regulation of Bone Remodeling. Annual Review of Biomedical Engineering Volume 8, pages 6.1-6.44 (PMID: 16834564).

Jacobs CR, Temiyasathit S, Castillo AB. (2010) Osteocyte Mechanobiology and Pericellular Mechanics. Annual Review of Biomedical Engineering, Volume 12, pages 369-400 (PMID: 20617941).

Castillo AB, Jacobs CR. (2010) Mesenchymal Stem Cell Mechanobiology. Current Osteoporosis Reports 8:98-104 (PMID: 20425617).

Castillo AB and Jacobs CR. (2011) Skeletal Mechanobiology. In: Mechanobiology Handbook. J. Nagatomi (Ed.), CRC Press, Boca Raton. Volume 9, pages 179-228. ISBN: 978-1-4200-9121-2.

Chen JC, Castillo AB, Jacobs CR. (2013) Cellular and Molecular Mechanotransduction in Bone In: Osteoporosis, 4th Edition. R. Marcus (Ed.), Academic Press, Waltham, MA. Volume 1, Chapter 20, pages 453-475. ISBN: 978-0-12-415853-5.

Awards + Distinctions

Alice L. Jee Young Investigator Award, Sun Valley Hard Tissue Workshop (2003)

Stanford Center on Longevity Postdoctoral Fellowship Award (2007)

American Society for Bone and Mineral Research Young Investigator Award (2007)

Career Development Award-2, Department of Veterans Affairs (2009)

CSURM Fellowship, Gordon Research Conference (2010)

Member-Elect, Orthopaedic Research Society Nominating Committee (2015)

Affiliations

NYU Center for Skeletal and Craniofacial Biology

Biomedical Engineering Society

Orthopaedic Research Society

American Society for Bone and Mineral Research

Tissue Engineering International & Regenerative Medicine Society

International Bone & Mineral Society

International Society for Stem Cell Research

Grants

Angiogenesis in skeletal repair, (PI)

NYU Clinical and Translational Science Institute, 10/15 to 03/16

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Regulatory mechanisms in load-induced bone formation, (PI)

Department of Veterans Affairs, 06/15 to 05/19

Mechanical stimulation in skeletal repair, (PI)

AO Foundation (Switzerland), 05/15 to 04/16

Visualization of mouse vasculature for the study of angiogenesis in bone repair, (PI)

NYU CSCB, 04/15 to 03/16

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