Cover Image Gallery
Cover Image Gallery
Textbook & Book Chapters
1. Raymond H. W. Lam and Weiqiang Chen, Biomedical Devices: Materials, Design, and Manufacturing, Springer Nature, 2020. ISBN 978-3- 030-24236-7.2. David W. Inglis, Majid Ebrahimi Warkiani, Mohammad A. Qasaimeh, Weiqiang Chen (Eds.), Microfluidics for Biosensing and Diagnostics, MDPI, 2020. ISBN 978-3-0365-0063-8.
3. Lanqi Gong, Weiyi Qian, Jie Tong, Apratim Bajpai, Weiqiang Chen, Micro-Tweezers and Force Microscopy Techniques for Single Cell Mechanobiological Analysis, Handbook of Single Cell Technologies, edited by Tuhin Subhra Santra and Fan-Gang Tseng, Springer, 2019. ISBN 978-981-10-8952-7.
4. Chao Ma, Jacob Harris, Renee-Tyler Tan Morales, Weiqiang Chen, Microfluidics for Immunoâoncology, Nanotechnology and Microfluidics, edited by Xingyu Jiang, Chunli Bai, Minghua Liu, Wiley-VCH, 2019. doi.org/10.1002/9783527818341.ch5
Journal Articles
Submitted / To be Submitted
1. Chao Ma, Huishu Wang, Lunan Liu, Jie Tong, Matthew T. Witkowski, Iannis Aifantis, Saba Ghassemi, Weiqiang Chen, A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapy, submitted.2. Yi Liu, Baoce Sun, Shuhuan Hu, Ngoc Luu, Jifeng Ren, Lelin Liu, Yun Qu, Ruolin Zhang, Ao Zhou, Denvid Lau, Patrick van Rijn, Weiqiang Chen, Raymond H. W. Lam, Three-dimensional cell morphology is mediated by curvature sensing and interfacial stress, submitted.
3. Wen Yang, Lang Zhou, Zhenzhen Zhang, Chao Ma, Zhengyang Gu, Chuanyu Wang, Matthew T. Witkowski, Yuan Tian, Elizabeth A. Lipke, Feng Ding, Iannis Aifantis, Weiqiang Chen, Pengyu Chen, Nanoplasmonic Mapping of Single-Cell Cytokine Secretomic Signatures in CAR T-Cell Cancer Therapy, submitted.
Selected Publications
1. Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen, Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel, Aging Cell, 2023, 00, e14036.2. Lunan Liu, Zhuoyu Zhang, Chao Ma, Matthew T. Witkowski, Iannis Aifanti, Saba Ghassemi, Weiqiang Chen, Computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapse, Journal for ImmunoTherapy of Cancer, 2022, 10, e005360.
3. Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis, NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia, Nature Immunology, 2022, 23, 1424-1432.
4. Weiyi Qian, Tarik Hadi, Michele Silvestro, Xiao Ma, Cristobal F. Rivera, Apratim Bajpai, Rui Li, Zijing Zhang, Hengdong Qu, Rayan Sleiman Tellaoui, Annanina Corsica, Ariadne L. Zias, Karan Garg, Thomas Maldonado, Bhama Ramkhelawon, Weiqiang Chen, Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1, Nature Communications, 2022, 13, 512.
5. Chao Ma, Matthew T. Witkowski, Jacob Harris, Igor Dolgalev, Sheetal Sreeram, Weiyi Qian, Jie Tong, Xin Chen, Iannis Aifantis, Weiqian Chen, Leukemia-on-a-Chip: Dissecting the chemo-resistance mechanisms in B-cell acute lymphoblastic leukemia bone marrow niche, Science Advances, 2020, 6, eaba5536.
6. Xin Cui, Chao Ma, Varshini Vasudevaraja, Jonathan Serrano, Jie Tong, Yansong Peng, Michael Delorenzo, Guomiao Shen, Joshua Frenster, Renee-Tyler Tan Morales, Weiyi Qian, Aristotelis Tsirigos, Andrew S. Chi, Rajan Jain, Sylvia C. Kurz, Erik P. Sulman, Dimitris Placantonakis, Matija Snuderl, Weiqiang Chen, Dissecting the heterogeneity of immunosuppressive tumor microenvironments in a Glioblastoma-on-a- chip for optimized anti-PD-1 immunotherapy, eLife, 2020, 9, e52253.
7. Qianbin Wang, Xiaoyu Xu, Apratim Bajpai, Weiyi Qian, Roy Chen, Weiqiang Chen, Energy-mediated Machinery Drives Cellular Mechanical Allostasis, Advanced Materials, 2019, 1900453.
8. Weiqiang Chen, Shuo Han, Weyi Qain, Shinuo Weng, Haiou Yang, Luis G. Villa-Diaz, Yubing Sun, Paul H. Krebsbach, Jianping Fu, Nanotopography directs moto neuron lineage of human pluripotent stem cells, Nanoscale, 2018, 10, 3556-3565.
9. W. Qian, L. Gong, Z. Zhang, A. Bajpai, C. Liu, A. B. Castillo, J. C. M. Teo, W. Chen, Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis, ACS Applied Materials & Interfaces, 2017, 9, 41794-41806.
10. S. Weng, Y. Shao, W. Chen, and J. Fu, Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis, Nature Materials, 2016, 15, 961-967.
11. W. Chen, S. G. Allen, A. K. Reka, W. Qian, S. Han, J. Zhao, L. Bao, V. Keshamouni, S. D. Merajver, J. Fu, Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous molecular expression and metastatic characteristics, BMC Cancer, 2016, 16, 614.
12. Y. Sun, K. M. Aw Yong, L. G. Villa-Diaz, X. Zhang, W. Chen, R. Philson, S. Weng, H. Xu, P. H. Krebsbach, and J. Fu, Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, 2014, 13, 599-604.
13. A. Singh, S. Suri, T. Lee, J. M.Chilton, M. T. Cooke, W. Chen, J. Fu, S. L. Stice, H. Lu, T. C. McDevitt, and A. J. Garcia, Adhesive strength based, label-free isolation of reprogrammed human induced pluripotent stem cells, Nature Methods, 2013, 10, 438-444.
14. W. Chen, S. Weng, F. Zhang, S. Allen, X. Li, L. Bao, R. H. W. Lam, J. A. Macoska, S. D. Merajver, and J. Fu, Nanoroughened surfaces fo efficient capture of circulating tumor cells without using capture antibodies, ACS Nano, 2013, 7, 566-575.
15. W. Chen, L. G. Villa-Diaz, Y. Sun, S. Weng, R. H. W. Lam, L. Han, R. Fan, P. H. Krebsbach, and J. Fu, Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells , ACS Nano, 2012, 6, 4094-4103.
Review Articles
1. Lang Zhou, Lunan Liu, Muammar Ali Chang, Chao Ma, Weiqiang Chen, Pengyu Chen, Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip, Biosensors and Bioelectronics, 2023, 225, 115064.2. Mei ElGindi, Jiranuwat Sapudom, Ibrahim Hamed Ibrahim, Mohamed Al-Sayegh, Weiqian Chen, Anna Garcia-Sabate, Jeremy Teo, May the Force Be with You (Or Not): The Immune System under Microgravity, Cells, , 2021, 10, 8, 1941.
3. Apratim Bajpai, Rui Li, Weiqiang Chen, The Cellular Mechanobiology of Aging: From Biology to Mechanics, Annals of the New York Academy of Sciences, 2020, 1491, 3-24.
4. Chao Ma, Yansong Peng, Hongtong Li, Weiqiang Chen, Organ-on-a-Chip: A new paradigm for drug development, Trends in Pharmacological Sciences, 2021, 42, 2, 119-133.
5. Rui Li, Chao Ma, Haogang Cai, Weiqiang Chen, The CAR T-cell Mechanoimmunology at a Glance, Advanced Science, 2020, 2002628.
6. Ini-Isabee Witzel, Rasha Nasser, Anna Sabate, Jiranuwat Sapudom, Chao Ma, Weiqiang Chen, Jeremy CM Teo, Deconstructing immune microenvironments of lymphoid tissues for reverse engineering, Advanced Healthcare Materials, 2018, 1801126.
7. Jiacheng He, Ayoola T. Brimmo, Mohammad A. Qasaimeh, Pengyu Chen, Weiqiang Chen, Recent Advances and Perspectives in Microfluidics-Based Single-Cell Biosensing Techniques, Small Methods, 2017, 1, 1700192.
8. Y. Zhang, A. Gorden, W. Qian, W. Chen, Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface, Advanced Healthcare Materials, 2015, 4, 1900-1914.
9. W. Qian, Y. Zhang, W. Chen, Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells, Small, 2015, 11, 3850-3872.
10. W. Qian, Y. Zhang, A. Gorden, W. Chen, Nanotopographic biomaterials for isolation of circulating tumor cells, Journal of Nanotechnology in Engineering and Medicine, 2014, 5, 040901.
11. X. Li, W. Chen, Z. Li, L. Li, H. Gu, and J. Fu. Emerging microengineering tools for functional analysis and phenotyping of blood cells, Trends in Biotechnology, 2014, 32, 586-594.
12. W. Chen, Y. Shao, X. Li, and J. Fu, Nanotopograghical surfaces for stem cell fate control: Engineering mechanobiology from the bottom, Nano Today, 2014, 9, 759-784.
13. W. Chen, N. Huang, X. Li, Z. T. Yu, K. Kurabayashi and J. Fu. Emerging microfluidic tools for functional immunophenotyping: A new potential paradigm for immune status characterization, Frontiers in Oncology, 2013, 3, 98.
Biosystems and Biomaterials for Cancer and Immune Engineering
1. Mei ElGindi, Jiranuwat Sapudom, Anna Garcia Sabate, Brian Chesney Quartey, Aseel Alatoom, Mohammed Al-Sayegh, Rui Li, Weiqiang Chen, Jeremy Teo, Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity, npj Aging, 2023, 9, 14.2. Lunan Liu, Zhuoyu Zhang, Chao Ma, Matthew T. Witkowski, Iannis Aifanti, Saba Ghassemi, Weiqiang Chen, Computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapse, Journal for ImmunoTherapy of Cancer, 2022, 10, e005360.
3. Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis, NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia, Nature Immunology, 2022, 23, 1424-1432.
4. Zhuoyu Zhang, Lunan Liu, Chao Ma, Weiqiang Chen, A computational model of cytokine release syndrome during CAR T-cell therapy, Advanced Therapeutics, 2022, 2200130.
5. Zhuoyu Zhang, Lunan Liu, Chao Ma, Xin Cui, Raymond H. W. Lam, Weiqian Chen, An in silico glioblastoma microenvironment model dissects the immunological mechanisms of resistance to PD-1 checkpoint blockade immunotherapy, Small Methods, 2021, 2100197.
6. Chao Ma, Matthew T. Witkowski, Jacob Harris, Igor Dolgalev, Sheetal Sreeram, Weiyi Qian, Jie Tong, Xin Chen, Iannis Aifantis, Weiqian Chen, Leukemia-on-a-Chip: Dissecting the chemo-resistance mechanisms in B-cell acute lymphoblastic leukemia bone marrow niche, Science Advances, 2020, 6, eaba5536.
7. Xin Cui, Chao Ma, Varshini Vasudevaraja, Jonathan Serrano, Jie Tong, Yansong Peng, Michael Delorenzo, Guomiao Shen, Joshua Frenster, Renee-Tyler Tan Morales, Weiyi Qian, Aristotelis Tsirigos, Andrew S. Chi, Rajan Jain, Sylvia C. Kurz, Erik P. Sulman, Dimitris Placantonakis, Matija Snuderl, Weiqiang Chen, Dissecting the heterogeneity of immunosuppressive tumor microenvironments in a Glioblastoma-on-a- chip for optimized anti-PD-1 immunotherapy, eLife, 2020, 9:e52253.
8. Matthew T Witkowski, Igor Dolgalev, Nikki A Evensen, Chao Ma, Tiffany Chambers, Kathryn G Roberts, Sheetal Sreeram, Yuling Dai Anastasia N Tikhonova, Audrey Lasry, Chunxu Qu, Deqing Pei, Cheng Cheng, Gabriel A Robbins, Joanna Pierro, Shanmugapriya Selvaraj, Valeria Mezzano, Marla Daves, Philip J Lupo, Michael E Scheurer, Cynthia A Loomis, Charles G Mullighan, Weiqiang Chen, Karen R Rabin, Aristotelis Tsirigos, William L Carroll, Iannis Aifantis, Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia, Cancer Cell, 2020, 6, 867-882.e12.
9. Muhammedin Deliorman, Farhad K. Janahi, Pavithra Sukumar, Roaa Alnemari, Samar Fadl, Ayoub Glia, Weiqiang Chen, Mohammad A. Qasaimeh, A microfluidic-atomic force microscopy platform for the capture and mechanical characterization of circulating tumor cells in prostate cancer, Microsystems & Nanoengineering, 2020, 6, 20.
10. Weiqiang Chen, Steven G. Allen, Weiyi Qian, Zifeng Peng, Shuo Han, Xiang Li, Yubing Sun, Chelsea Fournier, Liwei Bao, Raymond H.W. Lam, Sofia D. Merajver, and Jianping Fu, Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-like Cells, Small, 2019, 1802891.
11. Haoyu Wang, Renee-Tyler Tan Morales, Xin Cui, Jiongxian Huang, Weiyi Qian, Jie Tong, Weiqiang Chen, A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Immunomodulation, Advanced Healthcare Materials, 2018, 1801234.
12. Xin Cui, Renee-Tyler Tan Morales, Weiyi Qian, Haoyu Wang, Jean-Pierre Gagner, Igor Dolgalev, Dimitris Placantonakis, David Zagzag, Luisa Cimmino, Matija Snuderl, Raymond H. W. Lam, Weiqiang Chen, Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis, Biomaterials, 2018, 161, 164-178.
13. W. Chen, S. G. Allen, A. K. Reka, W. Qian, S. Han, J. Zhao, L. Bao, V. Keshamouni, S. D. Merajver, J. Fu, Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous molecular expression and metastatic characteristics, BMC Cancer, 2016, 16, 614.
14. S. Hu, G. Liu, W. Chen, X. Li, W. Lu, R. H. W. Lam, J. Fu, Multiparametric biomechanical and biochemical phenotypic profiling of single cancer cells using elasticity microcytometer, Small, 2016, 12, 2300-2311.
* Featured as the cover story of Small in MAy 4 2016 issue
15. W. Chen, S. Weng, F. Zhang, S. Allen, X. Li, L. Bao, R. H. W. Lam, J. A. Macoska, S. D. Merajver, and J. Fu, Nanoroughened surfaces fo efficient capture of circulating tumor cells without using capture antibodies, ACS Nano, 2013, 7, 566-575.
* Featured as the cover story of ACS Nano in January 2013 issue 16. Y. Wu, Y. Lu, W. Chen, J. Fu and R. Fan, In silico experimentation of glioma microenvironment development and anti-tumor therapy, PLoS Computational Biology, 2012, 8, e1002355.
Integrated Microfluidics for Immunomonitoring and Biosensing
1. Jiacheng He, Siqi Wu, Wu Chen, Albert Kim, Wen Yang, Chuanyu Wang, Zhengyang Gu, Jialiang Shen, Siyuan Dai, Weiqiang Chen, Pengyu Chen, Calligraphy of Nanoplasmonic Bioink-Based Multiplex Immunosensor for Precision Immune Monitoring and Modulation, ACS Applied Materials & Interfaces, 2023, 15, 43, 50047-50057.2. Benteng Ma, Xinya Liu, Zhuoyu Zhang, Chao Ma, Rashik Chand, Saee Patwardhan, Chuanyu Wang, Soracha D. Thamphiwatana, Pengyu Chen, Weiqiang Chen, A Digital Nanoplasmonic Microarray Immunosensor for Multiplexed Cytokine Monitoring during CAR T-Cell Therapy from a Leukemia Tumor Microenvironment Model, Biosensors and Bioelectronics, 2023, 115247.
3. Jiyu Li, Dinglong Hu, Chee Kent Lim, Jifeng Ren, Xin Yao, Chao Ma, Marcos, Weiqiang Chen, Patrick K. H. Lee, and Raymond H. W. Lam, Selective Single-Bacteria Extraction Based on Capture and Release of Microemulsion Droplets, Scientific Reports, 2022, 15461.
4. Jiacheng He, Lang Zhou, Gangtong Huang, Jialiang Shen, Wu Chen, Chuanyu Wang, Albert Kim, Zhuoyu Zhang, Weiqiang Chen, Siyuan Dai, Feng Ding, Pengyu Chen, Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide Aptamer, ACS Applied Materials & Interfaces, 2022, 14, 43, 48464-48475.
5. Chuanyu Wang, Chung-Hui Huang, Zhuangqiang Gao, Jialiang Shen, Jiacheng He, Alana MacLachlan, Chao Ma, Ya Chang, Wen Yang, Yuxin Cai, Yang Lou, Siyuan Dai, Weiqiang Chen, Feng Li, Pengyu Chen, Nanoplasmonic Sandwich Immunoassay for Tumor-Derived Exosome Detection and Exosomal PD-L1 Profiling, ACS Sensors, 021, 6, 3308-3319.
6. Pavithra Sukumar, Muhammedin Deliorman, Ayoola T. Brimmo, Roaa Alnemari, Deena Elsori, Weiqiang Chen, Mohammad A. Qasaimeh, Airplug-mediated isolation and centralization of single T cells in rectangular microwells for biosensing, Advanced Therapeutics, 2019, 1900085.
7. Yuxin Cai, Jingyi Zhu, Jiacheng He, Yang Wen, Weiqiang Chen, Pengyu Chen, Magnet Patterned Superparamagnetic Fe3O4/Au Core-Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay, Advanced Healthcare Materials, 2019, 8, 1801478.
8. Jingyi Zhu, Jiacheng He, Michael Verano, Ayoola T. Brimmo, Ayoub Glia, Mohammad A. Qasaimeh, Pengyu Chen, Jose O. Aleman, Weiqiang Chen, An Integrated Adipose-Tissue-On-Chip Nanoplasmonic Biosensing Platform for Investigating Obesity-associated Inflammation, Lab on a Chip, 2018, 18, 3550-3560.
* Selected as the Lab on a Chip Emerging Investigator series paper.
* Featured as the inside cover story of Lab on a Chip in December 2018, Issue 23. * Featured in the "Organ-, body- and disease-on-a-chip systems" themed collection. 9. Xin Cui, Ya Liu, Dinglong Hu, Weiyi Qian, Dong Sun, Weiqiang Chen, and Raymond H. W. Lam, A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification, Lab on a Chip, 2018, 18, 52-531.
10. S. Hill, W. Qian, W. Chen, and J. Fu. Surface micromachining of polydimethylsiloxane for microfluidics applications, Biomicrofluidics, 2016, 10, 054114.
11. X. Li, W. Chen, G. Liu, W. Lu, and J. Fu. Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface- micromachined microfiltration membranes, Lab on a Chip, 2014, 32, 586-594.
12. B. Oh, N. Huang, W. Chen, J. Seo, P. Chen, T. T. Cornell, T. P. Shanley, J. Fu, and K. Kurabayashi Integrated nanoplasmonic sensing in an optofluidic platform for human blood cellular functional immunoanalysis, ACS Nano, 2014, 8, 2667-2676.
13. W. Chen, N. Huang, B. Oh, R. H. W. Lam, R. Fan, T. T. Cornell, T. P. Shanley, K. Kurabayashi, and J. Fu, Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells, Advance Healthcare Materials, 2013, 2, 965-975.
* Featured as the cover story of Advanced Healthcare Materials in July 2013 issue. * Reported by Materials Views, Cover story: microfluidic immunophenotyping, July 30, 2013.
14. N. Huang, W. Chen, B. Oh, T. Cornell, T. Shanley, J. Fu and K. Kurabayashi, An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping, Lab on a Chip,2012, 12, 4093-4101.
15. W. Chen, R. H. W. Lam and J. Fu, Photolithographic surface micromachining of polydimethylsiloxane (PDMS), Lab on a Chip, 2012, 12, 391- 395.
* Selected as the Top 10 Most Accessed Articles in Lab on Chip in November & December of 2011. * Selected for the Jan. 9 2012 issue of Virtual Journal of Nanoscale Science & Technology.
Synthetic ex vivo Stem Cell Microenvironment
1. Alessandra Zanut, Rui Li, Ru Deng, Xiangyu Liu, Martin Rejhon, W. Chen, Marcus Weck, Giuseppe Maria de Peppo, Elisa Riedo, A Polymer Canvas with the Stiffness of the Bone Matrix to Study and Control Mesenchymal Stem Cell Response, Advanced Healthcare Materials, 2023, 2201503.2. Weiqiang Chen, Shuo Han, Weyi Qain, Shinuo Weng, Haiou Yang, Luis G. Villa-Diaz, Yubing Sun, Paul H. Krebsbach, and Jianping Fu, Nanotopography directs moto neuron lineage of human pluripotent stem cells, Nanoscale, 2018, 10, 3556-3565.
3. W. Qian, L. Gong, Z. Zhang, A. Bajpai, C. Liu, A. B. Castillo, J. C. M. Teo, W. Chen, Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis, ACS Applied Materials & Interfaces, 2017, 9, 41794-41806.
4. Y. Sun, K. M. Aw Yong, L. G. Villa-Diaz, X. Zhang, W. Chen, R. Philson, S. Weng, H. Xu, P. H. Krebsbach, and J. Fu, Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, 2014, 13, 599-604.
5. A. Singh, S. Suri, T. Lee, J. M.Chilton, M. T. Cooke, W. Chen, J. Fu, S. L. Stice, H. Lu, T. C. McDevitt, and A. J. Garcia, Adhesive strength based, label-free isolation of reprogrammed human induced pluripotent stem cells, Nature Methods, 2013, 10, 438-444.
* Highlighted by NIH Director's Blog by NIH director Dr. Francis Collins, Exploiting Stem Cell Stickiness for Sorting, May 16, 2013
* Commentary by Oscar J. Abilez & Joseph C. Wu, Stem cell isolation: Differential stickiness, Nature Materials, vol. 12, pp. 474-476,2013.
6. W. Chen, Y. Sun and J. Fu, Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity, Small, 2013, 9, 81-89.
* Featured as the front cover story of Small in January 2013 issue,
7. W. Chen, L. G. Villa-Diaz, Y. Sun, S. Weng, R. H. W. Lam, L. Han, R. Fan, P. H. Krebsbach, and J. Fu, Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells , ACS Nano, 2012, 6, 4094-4103.
8. Y. Sun, K. M. Aw Yong, L. G. Villa-Diaz, X. Zhang, W. Chen, R. Philson, S. Weng, H. Xu, P. H. Krebsbach, and J. Fu, Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, 2014, 13, 599-604.
Cell Mechanics and Mechanotransduction
1. Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen, Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel, Aging Cell, 2023, 00, e14036.2. Ngoc Luu, Shuhao Zhang, Raymond H. W. Lam, Weiqiang Chen, Mechanical Constraints in Tumor Guide Emergent Spatial Patterns of Glioblastoma Cancer Stem Cells, Mechanobiology in Medicine, 2024, 2, 1, 100027.
3. Weiyi Qian, Tarik Hadi, Michele Silvestro, Xiao Ma, Cristobal F. Rivera, Apratim Bajpai, Rui Li, Zijing Zhang, Hengdong Qu, Rayan Sleiman Tellaoui, Annanina Corsica, Ariadne L. Zias, Karan Garg, Thomas Maldonado, Bhama Ramkhelawon, Weiqiang Chen, Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1, Nature Communications, 2022, 13, 512.
4. Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen, Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation, Chemical Communications, 2021, 57, 12667-12670.
* Featured in the 2021 Chemical Communications Emerging Investigator themed collection
5. Xin Cui, Jie Tong, Jimmy Yau, Apratim Bajpai, Jing Yang, Yansong Peng, Mrinalini Singh, Weiyi Qian, Xiao Ma, Weiqiang Chen, Mechanical Forces Regulate Asymmetric Vascular Cell Alignment, Biophysical Journal, 2020, 119, 1771-1780.
6. Apratim Bajpai, Jie Tong, Weiyi Qian, Yansong Peng, Weiqiang Chen, The interplay between cell-cell and cell-matrix forces regulates cell migration dynamics, Biophysical Journal, 2019, 117, 1-10.
7. Tobias Lendenmann, Teseo Schneider, Jeremie Dumas, Marco Tarini, Apratim Bajpai, Weiqiang Chen, Dimos Poulikakos, Aldo Ferrari, Daniele Panozzo, Cellogram: On the Fly Traction Force Microscopy, Nano Letter, 2019, 19, 10, 6742-6750.
8. Qianbin Wang, Xiaoyu Xu, Apratim Bajpai, Weiyi Qian, Roy Chen, Weiqiang Chen, Energy-mediated Machinery Drives Cellular Mechanical Allostasis, Advanced Materials, 2019, 1900453.
9. Weiyi Qian, Weiqiang Chen, Probing single-cell mechanical allostasis using ultrasound tweezers, Cellular and Molecular Bioengineering, 2019, s12195-019-00578-z.
* Featured as part of the 2019 CMBE Young Innovators issue
10. C. Liu, X. Cui, T. M. Ackermann, V. Flamini, W. Chen, and A. B Castillo, Osteoblast-Derived Paracrine Factors Regulate Angiogenesis in Response to Mechanical Stimulation, Integrative Biology, 2016, 81, 785-794.
11. S. Weng, Y. Shao, W. Chen, and J. Fu, Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis, Nature Materials, 2016, 15, 961-967.
12. Y. Shao, J. M. Mann, W. Chen, and J. Fu, Global Architecture of F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction, Integrative Biology, 2014, 6, 300-311.
13. Z. Fan, Y. Sun, D. Chen, D. Tay, W. Chen, C. X. Deng, and J. Fu, Acoustic tweezing cytometry for live-cell subcellular control of intracellular cytoskeleton contractility, Scientific Reports, 2013, 3, 2176.
14. R. H. W. Lam, Y. Sun, W. Chen, and J. Fu, Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis, Lab on a Chip,2012, 12, 1865-1873.
* Selected for the May 1 2012 issue of Virtual Journal of Biological Physical Research.
Nanophotonics for Biosensing
1. W. Chen, K. P. Chen, M. D. Thoreson, A. V. Kildishev and V. M. Shalaev, Ultrathin, ultrasmooth and low-loss silver films via wetting and annealing, Applied Physics Letter, 2010, 97, 21107.
2. W. Chen, D. Thoreson, A. V. Kildishev and V. M. Shalaev, Fabrication and Optical Characterizations of Smooth Silver-Silica Nanocomposite Films, Laser Physics Letters, 2010, 7, 677-684.
3. W. Chen, M. D. Thoreson, S. Ishii, A. V. Kildishev and V. M. Shalaev, Ultra-thin ultra-smooth and low-loss silver films on a germanium wetting layer, Optics Express, 2010, 18, 5124-5134.
4. R. B. Nielsen, M. D. Thoreson, W. Chen, A. Kristensen, J. M. Hvam, V. M. Shalaev and A. Boltasseva, Toward superlensing with metal- dielectric composites and multilayers, Applied Physics B, 2010, 100, 93-100.