Biomechanics, Biosystems, and Bioengineering

Many exciting topics exist at the interface between biomedical science and micro/nanotechnology. Our research aims to develop and apply innovative micro/nanoscale technologies and integrated biosystems targeting important emerging areas of research at the forefront of engineering and medicine. Our research is mainly focusing on interdisciplinary researches that leverage the engineering advances in microfluidics, lab-on-a-chip and organ-on-a-chip systems, biomaterials, and biomanufacturing for new and improved solutions for emerging problems in cancer biology, immune engineering, and stem cell-based regenerative medicine. Our research aims to bridge these fields in engineering and medicine by micro-engineering cell behaviors and environments in engineered models and microsystems for disease diagnosis and modeling. Specific examples include engineering microfluidic lab-on-a-chip systems for single-cell sensing, immunomonitoring, circulating tumor cell capture and analysis, reconstituting organotypic tumor microenvironments for rapid disease diagnosis and prognosis, as well as synthetic micro/nanoscale ex vivo stem cell microenvironment that are desirable for functional tissue engineering and regenerative medicine. These novel micro/nanoengineered biomaterials and biosystems will not only permit advances in engineering but also greatly contribute to improving human health.

Muiltiple openings are available for postdoctoral fellow, graduate and undergraduate students in our lab. Please check Opening for more information.

Lab Gallery

The Research team in the 2018 BMES Conference on October 17, 2018

Science seminar in the Mott Hall IV Middle School on May 9, 2018

Jimmy Yau MS thesis defense on May 4, 2018

Group photo on December 22, 2017

The 2017 Summer Undergradaute Research Team: Phoebe Welch, Levan Asatiani, Jiong Xian Huang, Zijing Zhang, Fang Ni Zeng, Adam Grozvirt-Dramen, Joyce Yan

The biophysics team in the 2016 BMES Conference on October 6, 2016

Group photo on September 2, 2016

Group photo on June 12, 2015

Group dinner on June 12, 2015

Weiyi won the 2015 Best Mechanical Engineering PhD Qualifying Exam Performance Award

2015 Summer Undergradaute Research Participant Ahmed Aladly (from the New Jersey Institute of Technology) Working in the Lab

News

Novermber 8, 2018
We welcome our new postdoc Linru Xu to join our Lab!

October 17, 2018
Five of our works by Weiyi, Chao, Xin, Jingyi, and Renee were selected for oral talks in the 2018 BME conference in Atlanta.

October 9, 2018
Our paper An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation is published in Lab on a Chip and featured in the Emerging Investigator Series!

Auguest 29, 2018
Our collaborative reserarch project with Profs. Matija Snuderl and Dimitrisin Placantonakis in the School of Medcine was supported by the NIH NIBIB Trailblazer Award! The goal of this project is to bioengineer glioblastoma brain tumor microenvironment model for personalized immunotherapy.

Auguest 1, 2018
Our Lab now is a part of the new Biomedical Engineering Department.

July 10, 2018
Weiyi gave an talk on cancer stem cell mechanobiology in the 8th World Congress of Biomechanics(WCB 2018) in Dublin, Ireland.

June 21, 2018
Dr. Chen gave an keynote talk in the 10th International Symposium on Microchemistry and Microsystems (ISSM 2018) in Busan, Korea.

June 20, 2018
Chao gave an invited talk for our lab in the 17th Annual World Preclinical Congress (WPC 2018), the Cambridge Healthtech Institute Inaugural Tumoroids for Oncology Research Conference in Boston.

June 13, 2018
Lanqi passed his MS thesis defense. Congratulations!

May 4, 2018
Jimmy passed his MS thesis defense. Congratulations!

April 25, 2018
Dr. Chen gave an invited talk in the 2018 IEEE International Conference on Nano/Micro Engineered and Molecular Systems(IEEE NEMS 2018) in Singapore.

April 9, 2018
Renee-Tyler Tan Morales were awarded theAmerican Heart Association Undergraduate Student Summer Fellowship Award! Congratulations!

January 29, 2018
Our paper Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis is published in Biomaterials!

January 16, 2018
Our study of Nanotopography Regulates Motor Neuron Differentiation of Human Pluripotent Stem Cells is published in Nanoscale!

January 12, 2018
Our collaboritive study of A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification is published in Lab on a Chip!

January 8, 2018
We welcome our new postdoc Jie Tong to join our Lab!

January 6, 2018
Dr. Chen gave an talk in the 2018 Cellular and Molecular Bioengineering Conference (CMBE 2018) in Key Largo, Florida.

December 11, 2017
Dr. Chen gave an invited talk in the 3rd International Symposium on Mechanobiology (ISMB 2017) in Singapore.

Novermber 16, 2017
Our study of Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis is published in ACS Applied Materials & Interfaces!

August 22, 2017
Dr. Chen were awarded the NYU Goddard Junior Faculty Fellowship!

August 1, 2017
We welcome our new postdoc Chao Ma to join our Lab!

July 14, 2017
Dr. Chen chaired an Invited Session of "Microfluidic Systems for Cell Manipulation and Analysis" in the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in the Jeju Island, Korea.

July 13, 2017
Dr. Chen were awarded the NYU Whitehead Fellowship! The award will support out research on developing Glioma-on-a-Chip for in vitro Validation of Personalized Immunotherapyis.

July 5, 2017
We were awarded the NSF grant to develop Plasmofluidic Nanoantenna-Superlens Biosensor for Single-Cell Functional Immunophenotyping! NYU Tandon News: Understanding the Immune System on a Nano-scale

June 21, 2017
Our collaborative reserarch project "Nanomechanical Phenotyping of Prostate Circulating Tumor Cells" with Profs. Qasaimeh at NYU Abu Dhabi was supported by the NYUAD Research Enhancement Fund!

June 1, 2017
We welcome our new postdoc Jingyi Zhu and Haoyu Wang to join our Lab!

April 11, 2017
Xin gave an invited talk for our lab in the IEEE NEMS 2017 Conference in Los Angeles.

April 10, 2017
Dr. Chen chaired and gave an invited talk in the 1st NYU Biomedical and Biosystems Conference in NYU Abu Dhabi.

March 13, 2017
Our collaborative reserarch project with Profs. Matija Snuderl and Luisa Cimmino in the Department of Pathology was supported by the NYU mega-grant initiative award from the NYU Provost Office! The goal of this project is to bioengineer in vitro glioma microenvironment model for personalized immunotherapy.

February 15, 2017
We were awarded the NYU CTSI Translational Research Pilot Project Award for our collaborative reserarch project with Prof. Jose Aleman at the School of Medicine to develop new plsamo-microfluidic biosensing chip for single-cell phenotyping of human adipose tissue immune cells.

June 16, 2016
Our collaboraitve paper with Prof. Alesha B. Castillo's Lab Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation is published in Integrative Biology!

November 1, 2016
Dr. Chen gave an invited talk in the IEEE-NANOMED conference in Macau, China.

October 10, 2016
We welcome our new visiting PhD student Xin Sui to join our Lab!

October 5-8, 2016
Qianibn and Weyi presented their research in the 2016 BMES Conference.

August 9, 2016
Our study of Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics is published in BMC Cancer!

July 4, 2016
We welcome our new postdoc Xin Cui to join our Lab!

May 30, 2016
Our collaboraitve paper on Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis is published in Nature Materials!

May 20, 2016
We were awarded the American Heart Association Scientist Development Grant! The goal of this project is to study the nanotopography-dependent neural induction of human induced pluripotent stem cells.

March 10, 2016
We were awarded the NYU Global Seed Grant for Collaborative Reserarch with NYU Abu Dhabi (Prof. Qasaimeh) to develop new plsamonic biosensing chip for single cell phenotyping!

Jan 28, 2016
AMB Lab welcomes his newest postdoc, Qianbin, welcome on board!

August 9, 2015
Our review paper on Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface is published in Advanced Healthcare Materials!

April 27, 2015
Congratulations to Weiyi! He has just won the Best Mechanical Engineering PhD Qualifying Exam Performance Award!

March 9, 2015
Congratulations to Weiyi! His first review paper on Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells is published in Small!

February 26, 2015
Weiqiang has just won the UM ProQuest Distinguished Dissertation Award!

February 12, 2015
Congratulations to Weiyi! He has successfully passed ME Ph.D. qualifying exam!

December 20, 2014
AMB Lab welcomes Andrew, Nasir and Lanqi to join our Lab!

December 11, 2014
AMB Lab welcomes our new gradaute student, Affan to join our Lab. welcome on board!

September 1, 2014
AMB Lab welcomes his newest doctoral students. Weiyi and Yan, welcome on board!

September 1, 2014
Weiqiang has joined the Department of Mechanical and Aerospace Engineering of New York University as an assistant professor!