Course Information

CBE8113 Optimization in Biological Systems

Credits: 3.00

This course introduces the mathematical programming approach. Topics include tree and network representations; review of the basic concepts in optimization; Kuhn-Tucker optimality conditions; non-linear programming algorithms; modeling techniques for formulating non-linear models; review of linear programming; modeling of continuous and discrete decisions; mixed-integer linear programming techniques (MILP); logical inference and MILP; mixed-integer non-linear programming algorithms (MINLP); applications in computational molecular biology; genotyping of pooled micro-satellite markers; genome rearrangement by DNA inversions; multiple alignment problems; optimization applications in protein systems; and optimization applications in metabolic networks.

Prerequisite: Adviser’s approval.