This course introduces modern protein-engineering techniques available to researchers to understand protein structure and function and to create entirely new proteins for many purposes. This new field lies at the interface of chemistry, biology and engineering. The first section discusses protein composition and structure, and various genetic, biochemical and chemical techniques required to engineer proteins, followed by specific topics. Topics include designing highly structured proteins that are active at high temperatures and in non-aqueous solvents; that interact selectively with other proteins, small molecules and nucleic acids for therapeutic purposes; and that catalyze new reactions.
Prerequisite: Adviser’s approval.