This course introduces the modern protein engineering techniques that allow researchers to understand protein structure and function and to create new proteins for many purposes. This new field is at the interface of chemistry, biology and engineering. The first part of the course discusses the protein composition and structure, various genetic, biochemical and chemical techniques required to engineer proteins, which is followed by specific topics. Topics include designing proteins that are highly structured; that are active at high temperatures and in non-aqueous solvents; that interact selectively with other proteins, small molecules and nucleic acids for therapeutic purposes; and that catalyze new reactions.
Prerequisite: CM 9413 or adviser’s approval.