This course discusses various biosensors, which consist of bio-recognition systems, typically enzymes or binding proteins such as antibodies immobilized onto the surface of physico-chemical transducers. Immuno-sensors, which use antibodies as their biorecognition system, are also discussed. Other bio-recognition systems covered are nucleic acids, bacteria and whole tissues of higher organisms. Specific interactions between the target analyte and the complementary bio-recognition layer that undergoes a physicochemical change are ultimately detected and measured by the transducer. Various transducers, which can take many forms depending upon the parameters measured (electrochemical, optical, mass and thermal changes) are also covered.
Prerequisite: CM 1004, CM 2214, CM 2614 and CM 9413.